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Chios mastic gum extracts as a potent antitumor agent that inhibits growth and induces apoptosis of oral cancer cells.
DC Field | Value | Language |
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dc.contributor.author | 남웅 | - |
dc.contributor.author | 차인호 | - |
dc.date.accessioned | 2014-12-20T17:32:23Z | - |
dc.date.available | 2014-12-20T17:32:23Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1513-7368 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94789 | - |
dc.description.abstract | PURPOSE: The purpose was to investigate Chios mastic gum (CMG) extract as an potential anti-tumor agent for oral squamous cell carcinoma in vitro. METHODS: We designed a study to examine the effects of CMG extracts on growth of oral squamous cell carcinoma cell line, YD-10B and to determine whether the extracts could induce apoptosis through the activation of caspase-3, using the common chemotherapeutic agent Paclitaxel (Taxol, Bristol-Myers Squibb) as a control. RESULTS: MTT assay suggested that both CMG and Taxol inhibited the proliferation of YD-10B cells in a time and dose dependent manner. Moreover, 10 μg/mL of CMG and 50 μg/mL of Taxol caused fragmentation of the genomic DNA at 24 hour. Finally, 10 μg/mL of CMG and 50 μg/mL of Taxol caused cleavage of procaspase-3 in western blot analysis. CONCLUSIONS: These results suggest CMG's potential as an anti-tumor agent. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1877~1880 | - |
dc.relation.isPartOf | ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antineoplastic Agents, Phytogenic/pharmacology* | - |
dc.subject.MESH | Apoptosis/drug effects* | - |
dc.subject.MESH | Carcinoma, Squamous Cell/drug therapy | - |
dc.subject.MESH | Carcinoma, Squamous Cell/pathology | - |
dc.subject.MESH | Caspase 3/metabolism | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Proliferation/drug effects | - |
dc.subject.MESH | DNA/drug effects | - |
dc.subject.MESH | DNA/metabolism | - |
dc.subject.MESH | Drug Screening Assays, Antitumor | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mastic Resin | - |
dc.subject.MESH | Mouth Neoplasms/drug therapy* | - |
dc.subject.MESH | Mouth Neoplasms/pathology | - |
dc.subject.MESH | Paclitaxel/pharmacology | - |
dc.subject.MESH | Paclitaxel/therapeutic use | - |
dc.subject.MESH | Pistacia/chemistry | - |
dc.subject.MESH | Plant Extracts/pharmacology* | - |
dc.subject.MESH | Plant Extracts/therapeutic use | - |
dc.subject.MESH | Resins, Plant/pharmacology* | - |
dc.subject.MESH | Resins, Plant/therapeutic use | - |
dc.title | Chios mastic gum extracts as a potent antitumor agent that inhibits growth and induces apoptosis of oral cancer cells. | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral and Maxillofacial Surgery (구강악안면외과학) | - |
dc.contributor.googleauthor | ShengJin Li | - |
dc.contributor.googleauthor | In-Ho Cha | - |
dc.contributor.googleauthor | Woong Nam | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01260 | - |
dc.contributor.localId | A04002 | - |
dc.relation.journalcode | J00255 | - |
dc.identifier.eissn | 2476-762X | - |
dc.identifier.pmid | 22126583 | - |
dc.subject.keyword | Oral squamous cell carcinoma cells | - |
dc.subject.keyword | Chios mastic gum | - |
dc.subject.keyword | YD-10B cells | - |
dc.contributor.alternativeName | Nam, Woong | - |
dc.contributor.alternativeName | Cha, In Ho | - |
dc.contributor.affiliatedAuthor | Nam, Woong | - |
dc.contributor.affiliatedAuthor | Cha, In Ho | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 12 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1877 | - |
dc.citation.endPage | 1880 | - |
dc.identifier.bibliographicCitation | ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, Vol.12(7) : 1877-1880, 2011 | - |
dc.identifier.rimsid | 27754 | - |
dc.type.rims | ART | - |
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