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Chios mastic gum extracts as a potent antitumor agent that inhibits growth and induces apoptosis of oral cancer cells.

Authors
 ShengJin Li  ;  In-Ho Cha  ;  Woong Nam 
Citation
 ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, Vol.12(7) : 1877-1880, 2011 
Journal Title
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
ISSN
 1513-7368 
Issue Date
2011
MeSH
Antineoplastic Agents, Phytogenic/pharmacology* ; Apoptosis/drug effects* ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/pathology ; Caspase 3/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA/drug effects ; DNA/metabolism ; Drug Screening Assays, Antitumor ; Humans ; Mastic Resin ; Mouth Neoplasms/drug therapy* ; Mouth Neoplasms/pathology ; Paclitaxel/pharmacology ; Paclitaxel/therapeutic use ; Pistacia/chemistry ; Plant Extracts/pharmacology* ; Plant Extracts/therapeutic use ; Resins, Plant/pharmacology* ; Resins, Plant/therapeutic use
Keywords
Oral squamous cell carcinoma cells ; Chios mastic gum ; YD-10B cells
Abstract
PURPOSE: The purpose was to investigate Chios mastic gum (CMG) extract as an potential anti-tumor agent for oral squamous cell carcinoma in vitro.

METHODS: We designed a study to examine the effects of CMG extracts on growth of oral squamous cell carcinoma cell line, YD-10B and to determine whether the extracts could induce apoptosis through the activation of caspase-3, using the common chemotherapeutic agent Paclitaxel (Taxol, Bristol-Myers Squibb) as a control.

RESULTS: MTT assay suggested that both CMG and Taxol inhibited the proliferation of YD-10B cells in a time and dose dependent manner. Moreover, 10 μg/mL of CMG and 50 μg/mL of Taxol caused fragmentation of the genomic DNA at 24 hour. Finally, 10 μg/mL of CMG and 50 μg/mL of Taxol caused cleavage of procaspase-3 in western blot analysis.

CONCLUSIONS: These results suggest CMG's potential as an anti-tumor agent.
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Nam, Woong(남웅) ORCID logo https://orcid.org/0000-0003-0146-3624
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94789
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