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Chios mastic gum extracts as a potent antitumor agent that inhibits growth and induces apoptosis of oral cancer cells.

 ShengJin Li  ;  In-Ho Cha  ;  Woong Nam 
 Asian Pacific Journal of Cancer Prevention, Vol.12(7) : 1877-1880, 2011 
Journal Title
 Asian Pacific Journal of Cancer Prevention 
Issue Date
PURPOSE: The purpose was to investigate Chios mastic gum (CMG) extract as an potential anti-tumor agent for oral squamous cell carcinoma in vitro. METHODS: We designed a study to examine the effects of CMG extracts on growth of oral squamous cell carcinoma cell line, YD-10B and to determine whether the extracts could induce apoptosis through the activation of caspase-3, using the common chemotherapeutic agent Paclitaxel (Taxol, Bristol-Myers Squibb) as a control. RESULTS: MTT assay suggested that both CMG and Taxol inhibited the proliferation of YD-10B cells in a time and dose dependent manner. Moreover, 10 μg/mL of CMG and 50 μg/mL of Taxol caused fragmentation of the genomic DNA at 24 hour. Finally, 10 μg/mL of CMG and 50 μg/mL of Taxol caused cleavage of procaspase-3 in western blot analysis. CONCLUSIONS: These results suggest CMG's potential as an anti-tumor agent.
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실)
Yonsei Authors
남웅(Nam, Woong) ; 차인호(Cha, In Ho)
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