Cited 15 times in
Effects of lowering dialysate calcium concentrations on arterial stiffness in patients undergoing hemodialysis
DC Field | Value | Language |
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dc.contributor.author | 김좌경 | - |
dc.contributor.author | 박형천 | - |
dc.contributor.author | 심성록 | - |
dc.contributor.author | 이재성 | - |
dc.contributor.author | 하성규 | - |
dc.date.accessioned | 2014-12-20T17:31:52Z | - |
dc.date.available | 2014-12-20T17:31:52Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94772 | - |
dc.description.abstract | BACKGROUND/AIMS: We assessed changes in hemodynamic and arterial stiffness parameters following reductions of dialysate calcium concentrations in patients undergoing hemodialysis. METHODS: In this prospective study, 20 patients on maintenance hemodialysis (10 females, 10 males) with dialysate calcium concentrations of 1.75 mmol/L were enrolled. At the start of the study, the dialysate calcium level was lowered to 1.50 mmol/L. Serial changes in biochemical, hemodynamic, and arterial stiffness parameters, including pulse wave velocity (PWV) and augmentation index (AIx), were assessed every 2 months for 6 months. We also examined changes in the calcification-inhibitory protein, serum fetuin-A. RESULTS: During the 6-month study period, serum total calcium and ionized calcium decreased consistently (9.5 ± 1.0 to 9.0 ± 0.7, p = 0.002 vs. 1.3 ± 0.1 to 1.1 ± 0.1, p = 0.035). Although no apparent changes in blood pressure were observed, heart-femoral PWW (hf-PWV) and AIx showed significant improvement (p = 0.012, 0.043, respectively). Repeated-measures ANOVA indicated a significant effect of lowering dialysate calcium on hf-PWV (F = 4.58, p = 0.004) and AIx (F = 2.55, p = 0.049). Accompanying the change in serum calcium, serum fetuin-A levels significantly increased (95.8 ± 45.8 pmol/mL at baseline to 124.9 ± 82.2 pmol/mL at 6 months, p = 0.043). CONCLUSIONS: Lowering dialysate calcium concentration significantly improved arterial stiffness parameters, which may have been associated with upregulation of serum fetuin-A. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 320~327 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Ankle Brachial Index | - |
dc.subject.MESH | Arteries/drug effects* | - |
dc.subject.MESH | Arteries/physiopathology | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Blood Pressure/drug effects | - |
dc.subject.MESH | Calcium/administration & dosage* | - |
dc.subject.MESH | Calcium/adverse effects | - |
dc.subject.MESH | Compliance | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hemodialysis Solutions/administration & dosage* | - |
dc.subject.MESH | Hemodialysis Solutions/adverse effects | - |
dc.subject.MESH | Hemodialysis Solutions/chemistry | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Pulsatile Flow/drug effects* | - |
dc.subject.MESH | Renal Dialysis* | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | alpha-2-HS-Glycoprotein/metabolism | - |
dc.title | Effects of lowering dialysate calcium concentrations on arterial stiffness in patients undergoing hemodialysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jwa-Kyung Kim | - |
dc.contributor.googleauthor | Sung Jin Moon | - |
dc.contributor.googleauthor | Hyeong Cheon Park | - |
dc.contributor.googleauthor | Jae Sung Lee | - |
dc.contributor.googleauthor | Soung Rok Sim | - |
dc.contributor.googleauthor | Sung Chang Bae | - |
dc.contributor.googleauthor | Sung Kyu Ha | - |
dc.identifier.doi | 10.3904/kjim.2011.26.3.320 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00931 | - |
dc.contributor.localId | A01759 | - |
dc.contributor.localId | A02194 | - |
dc.contributor.localId | A03075 | - |
dc.contributor.localId | A04252 | - |
dc.relation.journalcode | J02883 | - |
dc.identifier.eissn | 2005-6648 | - |
dc.identifier.pmid | 22016593 | - |
dc.subject.keyword | Arterial stiffness | - |
dc.subject.keyword | Calcium | - |
dc.subject.keyword | Dialysis solutions | - |
dc.subject.keyword | Fetuin A | - |
dc.subject.keyword | Hemodialysis | - |
dc.contributor.alternativeName | Kim, Jwa Kyung | - |
dc.contributor.alternativeName | Park, Hyeong Cheon | - |
dc.contributor.alternativeName | Sim, Soung Rok | - |
dc.contributor.alternativeName | Lee, Jae Sung | - |
dc.contributor.alternativeName | Ha, Sung Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Jwa Kyung | - |
dc.contributor.affiliatedAuthor | Park, Hyeong Cheon | - |
dc.contributor.affiliatedAuthor | Sim, Soung Rok | - |
dc.contributor.affiliatedAuthor | Lee, Jae Sung | - |
dc.contributor.affiliatedAuthor | Ha, Sung Kyu | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 26 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 320 | - |
dc.citation.endPage | 327 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF INTERNAL MEDICINE, Vol.26(3) : 320-327, 2011 | - |
dc.identifier.rimsid | 27741 | - |
dc.type.rims | ART | - |
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