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Effects of lowering dialysate calcium concentrations on arterial stiffness in patients undergoing hemodialysis

DC Field Value Language
dc.contributor.author김좌경-
dc.contributor.author박형천-
dc.contributor.author심성록-
dc.contributor.author이재성-
dc.contributor.author하성규-
dc.date.accessioned2014-12-20T17:31:52Z-
dc.date.available2014-12-20T17:31:52Z-
dc.date.issued2011-
dc.identifier.issn1226-3303-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/94772-
dc.description.abstractBACKGROUND/AIMS: We assessed changes in hemodynamic and arterial stiffness parameters following reductions of dialysate calcium concentrations in patients undergoing hemodialysis. METHODS: In this prospective study, 20 patients on maintenance hemodialysis (10 females, 10 males) with dialysate calcium concentrations of 1.75 mmol/L were enrolled. At the start of the study, the dialysate calcium level was lowered to 1.50 mmol/L. Serial changes in biochemical, hemodynamic, and arterial stiffness parameters, including pulse wave velocity (PWV) and augmentation index (AIx), were assessed every 2 months for 6 months. We also examined changes in the calcification-inhibitory protein, serum fetuin-A. RESULTS: During the 6-month study period, serum total calcium and ionized calcium decreased consistently (9.5 ± 1.0 to 9.0 ± 0.7, p = 0.002 vs. 1.3 ± 0.1 to 1.1 ± 0.1, p = 0.035). Although no apparent changes in blood pressure were observed, heart-femoral PWW (hf-PWV) and AIx showed significant improvement (p = 0.012, 0.043, respectively). Repeated-measures ANOVA indicated a significant effect of lowering dialysate calcium on hf-PWV (F = 4.58, p = 0.004) and AIx (F = 2.55, p = 0.049). Accompanying the change in serum calcium, serum fetuin-A levels significantly increased (95.8 ± 45.8 pmol/mL at baseline to 124.9 ± 82.2 pmol/mL at 6 months, p = 0.043). CONCLUSIONS: Lowering dialysate calcium concentration significantly improved arterial stiffness parameters, which may have been associated with upregulation of serum fetuin-A.-
dc.description.statementOfResponsibilityopen-
dc.format.extent320~327-
dc.relation.isPartOfKOREAN JOURNAL OF INTERNAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAnalysis of Variance-
dc.subject.MESHAnkle Brachial Index-
dc.subject.MESHArteries/drug effects*-
dc.subject.MESHArteries/physiopathology-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHBlood Pressure/drug effects-
dc.subject.MESHCalcium/administration & dosage*-
dc.subject.MESHCalcium/adverse effects-
dc.subject.MESHCompliance-
dc.subject.MESHFemale-
dc.subject.MESHHemodialysis Solutions/administration & dosage*-
dc.subject.MESHHemodialysis Solutions/adverse effects-
dc.subject.MESHHemodialysis Solutions/chemistry-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHPulsatile Flow/drug effects*-
dc.subject.MESHRenal Dialysis*-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHalpha-2-HS-Glycoprotein/metabolism-
dc.titleEffects of lowering dialysate calcium concentrations on arterial stiffness in patients undergoing hemodialysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJwa-Kyung Kim-
dc.contributor.googleauthorSung Jin Moon-
dc.contributor.googleauthorHyeong Cheon Park-
dc.contributor.googleauthorJae Sung Lee-
dc.contributor.googleauthorSoung Rok Sim-
dc.contributor.googleauthorSung Chang Bae-
dc.contributor.googleauthorSung Kyu Ha-
dc.identifier.doi10.3904/kjim.2011.26.3.320-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00931-
dc.contributor.localIdA01759-
dc.contributor.localIdA02194-
dc.contributor.localIdA03075-
dc.contributor.localIdA04252-
dc.relation.journalcodeJ02883-
dc.identifier.eissn2005-6648-
dc.identifier.pmid22016593-
dc.subject.keywordArterial stiffness-
dc.subject.keywordCalcium-
dc.subject.keywordDialysis solutions-
dc.subject.keywordFetuin A-
dc.subject.keywordHemodialysis-
dc.contributor.alternativeNameKim, Jwa Kyung-
dc.contributor.alternativeNamePark, Hyeong Cheon-
dc.contributor.alternativeNameSim, Soung Rok-
dc.contributor.alternativeNameLee, Jae Sung-
dc.contributor.alternativeNameHa, Sung Kyu-
dc.contributor.affiliatedAuthorKim, Jwa Kyung-
dc.contributor.affiliatedAuthorPark, Hyeong Cheon-
dc.contributor.affiliatedAuthorSim, Soung Rok-
dc.contributor.affiliatedAuthorLee, Jae Sung-
dc.contributor.affiliatedAuthorHa, Sung Kyu-
dc.rights.accessRightsfree-
dc.citation.volume26-
dc.citation.number3-
dc.citation.startPage320-
dc.citation.endPage327-
dc.identifier.bibliographicCitationKOREAN JOURNAL OF INTERNAL MEDICINE, Vol.26(3) : 320-327, 2011-
dc.identifier.rimsid27741-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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