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Differentially expressed microRNAs in pancreatic cancer stem cells

Authors
 Jung, Dawoon E. ; Wen, Jing ; Song, Si Young ; Oh, Taeyun 
Citation
 Pancreas, Vol.40(8) : 1180~1187, 2011 
Journal Title
 Pancreas 
ISSN
 0885-3177 
Issue Date
2011
Abstract
OBJECTIVE: The objective of this study was to analyze and identify pancreatic cancer stem cell-specific microRNAs (miRNAs) and messenger RNAs (mRNAs) to investigate their correlations to cancer stem cell biology. METHODS: We used sphere cultivation methods to enrich the stem cell population and analyzed overall miRNA and mRNA expressions using microarray analysis. RESULTS: Differentially expressed miRNAs including miR-99a, miR-100, miR-125b, miR-192, and miR-429 were detected in pancreatic cancer stem cells. Furthermore, examining both profiles, we obtained 210 miRNAs and 258 stem cell-associated mRNAs that were differentially expressed in the pancreatic cancer stem cells. These miRNAs and mRNAs were further investigated using cross-correlation analysis, which yielded 6 groups of miRNAs and 3 groups of mRNAs. The number of miRNA clusters and mRNA clusters showed high correlation based on microarray result. CONCLUSIONS: Differentially expressed miRNAs in pancreatic cancer stem cells provide insights into possible linkages between clusters of miRNAs and clusters of stem cell-associated mRNAs in cancer stem cells and have broad implications in our understanding of cancer stem cells and cancer stem cell-targeted cancer therapy.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94759
DOI
10.1097/MPA.0b013e318221b33e
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Institute of Gastroenterology
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006676-201111000-00004&LSLINK=80&D=ovft
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