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복구효소를 이용한 손상된 DNA의 STR 유전자형 분석

DC Field Value Language
dc.contributor.author심정은-
dc.contributor.author양우익-
dc.contributor.author이환영-
dc.contributor.author신경진-
dc.date.accessioned2014-12-20T17:30:36Z-
dc.date.available2014-12-20T17:30:36Z-
dc.date.issued2011-
dc.identifier.issn1225-0589-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/94732-
dc.description.abstractDNA found at the scene of a crime is often damaged and degraded to small fragments and remained in low quantity. Therefore, there are some difficulties in forensic STR typing of these DNA samples. In this study, to overcome these limitations as different approach, we applied repairing enzyme to damaged DNA. The efficacy of a repair enzyme system (PreCR Repair Mix) was evaluated by using several types of artificially damaged and naturally damaged DNA. The results showed that autosomal STR amplification produced increased yield in the DNA damaged by UV irradiation, oxidation, or acid/heat, and DNA from dried blood spot and dried saliva spot by treatment of a repair enzyme, but not in DNA extracted from old skeletal remains. In conclusion, a repair enzyme will be efficiently applied to forensic samples which were damaged by UV irradiation, oxidation, and acid/heat-
dc.description.statementOfResponsibilityopen-
dc.format.extent114~119-
dc.relation.isPartOfKorean Journal of Legal Medicine (대한법의학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title복구효소를 이용한 손상된 DNA의 STR 유전자형 분석-
dc.title.alternativeApplication of a Repair Enzyme to STR Analysis of Damaged DNA-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthor심정은-
dc.contributor.googleauthor이환영-
dc.contributor.googleauthor양우익-
dc.contributor.googleauthor이승환-
dc.contributor.googleauthor신경진-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02210-
dc.contributor.localIdA02300-
dc.contributor.localIdA03335-
dc.contributor.localIdA02085-
dc.relation.journalcodeJ02046-
dc.subject.keywordrepair enzyme-
dc.subject.keywordSTR-
dc.subject.keyworddamaged DNA-
dc.contributor.alternativeNameSim, Jeong Eun-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.alternativeNameLee, Hwan Young-
dc.contributor.alternativeNameShin, Kyoung Jin-
dc.contributor.affiliatedAuthorSim, Jeong Eun-
dc.contributor.affiliatedAuthorYang, Woo Ick-
dc.contributor.affiliatedAuthorLee, Hwan Young-
dc.contributor.affiliatedAuthorShin, Kyoung Jin-
dc.rights.accessRightsfree-
dc.citation.volume35-
dc.citation.number2-
dc.citation.startPage114-
dc.citation.endPage119-
dc.identifier.bibliographicCitationKorean Journal of Legal Medicine (대한법의학회지), Vol.35(2) : 114-119, 2011-
dc.identifier.rimsid27717-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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