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80세 이상 급성기 허혈뇌졸중 환자에서 정맥내 혈전 용해 치료를 결정하는데 연관된 요인
DC Field | Value | Language |
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dc.contributor.author | 남효석 | - |
dc.contributor.author | 차명진 | - |
dc.contributor.author | 허지회 | - |
dc.date.accessioned | 2014-12-20T17:29:58Z | - |
dc.date.available | 2014-12-20T17:29:58Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1229-4101 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94714 | - |
dc.description.abstract | Background Small proportions of all the elderly stroke patients receive recombinant tissue plasminogen activator (r-tPA) therapy, although old age is not a proven contraindication to intravenous thrombolytic therapy for acute ischemic stroke. The purpose of this study was to identify reasons for exclusion from r-tPA therapy and factors associated with the decision of r-tPA use in elderly patients with acute ischemic stroke. Methods From the acute stroke registries of 22 domestic university hospitals taking the r-tPA therapy from January 2007 to May 2010, we extracted data of all acute ischemic stroke patients who were aged 80 or over and arrived within onset 3 hours. For all patients, we assessed the eligibility of r-tPA therapy using National Institute of Neurological Disorders and Stroke (NINDS) r-tPA trial criteria. For eligible patients, we compared all clinical variables between patients who were treated with r-tPA and those who were not, and analyzed potential factors related to the decision of r-tPA use. Results A total of 494 patients were included in this study. 255 patients (51.6%) were excluded by NINDS r-tPA trial criteria and the major reasons for exclusion were minor neurological deficit (53.7%) and clinical improvement (17.3%). Among 239 patients who were eligible for r-tPA, 162 (32.8%) patients received r-tPA and 77 (15.6%) did not. Multivariable analysis showed that younger age, shorter time-delay from onset to admission, non-smoker, no history of prior stroke, good pre-stroke functional status and severe initial neurological deficit were independently associated with the decision of r-tPA use in the elderly stroke patients predictors for r-tPA treatment. Conclusion In very elderly patients, mild neurological deficit on arrival and rapid clinical improvement in neurological symptoms were the main reasons for exclusion from thrombolytic therapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 79~84 | - |
dc.relation.isPartOf | Korean Journal of Stroke (대한뇌졸중학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 80세 이상 급성기 허혈뇌졸중 환자에서 정맥내 혈전 용해 치료를 결정하는데 연관된 요인 | - |
dc.title.alternative | The Factors Associated with the Decision of r-tPA Use in Acute Ischemic Stroke Patients Aged 80 Years or Older | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | 정민경 | - |
dc.contributor.googleauthor | 김예림 | - |
dc.contributor.googleauthor | 김여진 | - |
dc.contributor.googleauthor | 오미선 | - |
dc.contributor.googleauthor | 유경호 | - |
dc.contributor.googleauthor | 이병철 | - |
dc.contributor.googleauthor | 이주헌 | - |
dc.contributor.googleauthor | 권지현 | - |
dc.contributor.googleauthor | 권순억 | - |
dc.contributor.googleauthor | 허성혁 | - |
dc.contributor.googleauthor | 최재철 | - |
dc.contributor.googleauthor | 권형민 | - |
dc.contributor.googleauthor | 박종무 | - |
dc.contributor.googleauthor | 김응규 | - |
dc.contributor.googleauthor | 나정호 | - |
dc.contributor.googleauthor | 박희권 | - |
dc.contributor.googleauthor | 배희준 | - |
dc.contributor.googleauthor | 한문구 | - |
dc.contributor.googleauthor | 홍근식 | - |
dc.contributor.googleauthor | 조용진 | - |
dc.contributor.googleauthor | 박만석 | - |
dc.contributor.googleauthor | 조기현 | - |
dc.contributor.googleauthor | 김한영 | - |
dc.contributor.googleauthor | 이 준 | - |
dc.contributor.googleauthor | 김동억 | - |
dc.contributor.googleauthor | 이수주 | - |
dc.contributor.googleauthor | 이경복 | - |
dc.contributor.googleauthor | 박태환 | - |
dc.contributor.googleauthor | 차명진 | - |
dc.contributor.googleauthor | 허지회 | - |
dc.contributor.googleauthor | 남효석 | - |
dc.contributor.googleauthor | 차재관 | - |
dc.contributor.googleauthor | 김철호 | - |
dc.contributor.googleauthor | 윤병우 | - |
dc.identifier.doi | 10.5853/kjs.2011.13.2.79 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01273 | - |
dc.contributor.localId | A03993 | - |
dc.contributor.localId | A04369 | - |
dc.relation.journalcode | J02121 | - |
dc.subject.keyword | Stroke | - |
dc.subject.keyword | Thrombolysis | - |
dc.subject.keyword | Tissue plasminogen activation | - |
dc.subject.keyword | Elderly | - |
dc.subject.keyword | Exclusion | - |
dc.contributor.alternativeName | Nam, Hyo Suk | - |
dc.contributor.alternativeName | Cha, Myoung Jin | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Nam, Hyo Suk | - |
dc.contributor.affiliatedAuthor | Cha, Myoung Jin | - |
dc.contributor.affiliatedAuthor | Heo, Ji Hoe | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 79 | - |
dc.citation.endPage | 84 | - |
dc.identifier.bibliographicCitation | Korean Journal of Stroke (대한뇌졸중학회지), Vol.13(2) : 79-84, 2011 | - |
dc.identifier.rimsid | 27701 | - |
dc.type.rims | ART | - |
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