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Gold nanostructures as photothermal therapy agent for cancer.

Authors
 Jihye Choi ; Jaemoon Yang ; Seungjoo Haam ; Kwangyeol Lee ; Yong-Min Huh ; Jin-Suck Suh ; Eunji Jang 
Citation
 Antimicrobial Agents and Chemotherapy, Vol.11(10) : 953~964, 2011 
Journal Title
 Antimicrobial Agents and Chemotherapy 
ISSN
 1871-5206 
Issue Date
2011
Abstract
Well-designed photothermal nanostructures have attracted many scientists pursuing a better means to accurately diagnose cancer and assess the efficacy of treatment. Recently, gold-based nanostructures (nanoshells, nanorods and nanocages) have enabled photothermal ablation of cancer cells with near-infrared (NIR) light without damaging normal human tissues and in particular, animal studies and early clinical testing showed the great promise for these materials. In this review article, we first discuss the mechanism of the cellular death signaling by thermal stress and introduce the intrinsic properties of gold nanostructures as photothermal agent for cancer treatment. Then the overview follows for evolving researches for the synthesis of various types of gold nanostructures and for their biomedical applications. Finally we introduce the optimized therapeutic strategies involving nanoparticle surface modification and laser operation method for an enhanced accumulation of gold nanostructures to the target cancer as well as for an effective cancer cell ablation.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94635
DOI
10.2174/187152011797927599
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
1. 연구논문 > 5. Research Institutes > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease
Yonsei Authors
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Link
 http://www.eurekaselect.com/75496/article
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