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Gold nanostructures as photothermal therapy agent for cancer.

Authors
 Jihye Choi  ;  Jaemoon Yang  ;  Eunji Jang  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Kwangyeol Lee  ;  Seungjoo Haam 
Citation
 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol.11(10) : 953-964, 2011 
Journal Title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN
 0066-4804 
Issue Date
2011
MeSH
Animals ; Gold/chemistry* ; Gold/therapeutic use* ; Humans ; Hyperthermia, Induced/methods* ; Nanostructures/chemistry* ; Nanostructures/therapeutic use* ; Nanostructures/ultrastructure ; Neoplasms/therapy*
Keywords
Gold nanostructures ; photothermal therapy ; Near-IR ; cancer ; chemotherapy ; apoptosis ; procaspase ; anti-HER2-conjugated gold nanoshells
Abstract
Well-designed photothermal nanostructures have attracted many scientists pursuing a better means to accurately diagnose cancer and assess the efficacy of treatment. Recently, gold-based nanostructures (nanoshells, nanorods and nanocages) have enabled photothermal ablation of cancer cells with near-infrared (NIR) light without damaging normal human tissues and in particular, animal studies and early clinical testing showed the great promise for these materials. In this review article, we first discuss the mechanism of the cellular death signaling by thermal stress and introduce the intrinsic properties of gold nanostructures as photothermal agent for cancer treatment. Then the overview follows for evolving researches for the synthesis of various types of gold nanostructures and for their biomedical applications. Finally we introduce the optimized therapeutic strategies involving nanoparticle surface modification and laser operation method for an enhanced accumulation of gold nanostructures to the target cancer as well as for an effective cancer cell ablation.
Full Text
http://www.eurekaselect.com/75496/article
DOI
10.2174/187152011797927599
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94635
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