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Dissemination of IMP-6 metallo-β-lactamase-producing Pseudomonas aeruginosa sequence type 235 in Korea.

DC Field Value Language
dc.contributor.author이경원-
dc.contributor.author정석훈-
dc.date.accessioned2014-12-20T17:27:09Z-
dc.date.available2014-12-20T17:27:09Z-
dc.date.issued2011-
dc.identifier.issn0305-7453-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/94629-
dc.description.abstractOBJECTIVES: To investigate the epidemiological traits of Pseudomonas aeruginosa clinical isolates producing metallo-β-lactamases (MBLs) in Korea. METHODS: A total of 386 non-duplicate P. aeruginosa clinical isolates were collected from Korea in 2009. Detection of MBL genes was performed by PCR. The genetic organization of class 1 integrons carrying the MBL gene cassette was investigated by PCR mapping and sequencing. The epidemiological relationships of the isolates were investigated by multilocus sequence typing and PFGE. RESULTS: Of 386 P. aeruginosa isolates, 30 (7.8%) isolates carried the bla(IMP-6) gene and 1 (0.3%) isolate carried the bla(VIM-2) gene. A probe specific for the bla(IMP-6) gene was hybridized to an ∼950 kbp I-CeuI-macrorestriction fragment from all 30 isolates and a probe specific for the bla(VIM-2) gene also hybridized to an ∼500 kbp I-CeuI-macrorestriction fragment from 1 isolate (BDC10). All 31 MBL-producing isolates shared an identical sequence type (ST), ST235, and they carried the same bla(OXA-50) allelic type, bla(OXA-50g). All MBL-producing isolates showed similar XbaI-macrorestriction patterns (similarity >85%), irrespective of MBL genotype. CONCLUSIONS: P. aeruginosa ST235 carrying the chromosomally located bla(IMP-6) gene is widely disseminated in Korea-
dc.description.statementOfResponsibilityopen-
dc.format.extent2791~2796-
dc.relation.isPartOfJOURNAL OF ANTIMICROBIAL CHEMOTHERAPY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCluster Analysis-
dc.subject.MESHDNA, Bacterial/chemistry-
dc.subject.MESHDNA, Bacterial/genetics-
dc.subject.MESHElectrophoresis, Gel, Pulsed-Field-
dc.subject.MESHGenotype-
dc.subject.MESHHumans-
dc.subject.MESHMolecular Epidemiology-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHMultilocus Sequence Typing-
dc.subject.MESHPolymerase Chain Reaction-
dc.subject.MESHPseudomonas Infections/epidemiology*-
dc.subject.MESHPseudomonas Infections/microbiology*-
dc.subject.MESHPseudomonas aeruginosa/classification*-
dc.subject.MESHPseudomonas aeruginosa/enzymology*-
dc.subject.MESHPseudomonas aeruginosa/genetics-
dc.subject.MESHPseudomonas aeruginosa/isolation & purification-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHSequence Analysis, DNA-
dc.subject.MESHbeta-Lactamases/genetics-
dc.subject.MESHbeta-Lactamases/secretion*-
dc.titleDissemination of IMP-6 metallo-β-lactamase-producing Pseudomonas aeruginosa sequence type 235 in Korea.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorYoonmi Seok-
dc.contributor.googleauthorIl Kwon Bae-
dc.contributor.googleauthorSeok Hoon Jeong-
dc.contributor.googleauthorSoo Hyun Kim-
dc.contributor.googleauthorHyukmin Lee-
dc.contributor.googleauthorKyungwon Lee-
dc.identifier.doi10.1093/jac/dkr381-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02649-
dc.contributor.localIdA03619-
dc.relation.journalcodeJ01237-
dc.identifier.eissn1460-2091-
dc.identifier.pmid21933788-
dc.subject.keywordMBLs-
dc.subject.keywordmeropenem-
dc.subject.keywordclonal complex 235-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.alternativeNameJeong, Seok Hoon-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorJeong, Seok Hoon-
dc.rights.accessRightsfree-
dc.citation.volume66-
dc.citation.number12-
dc.citation.startPage2791-
dc.citation.endPage2796-
dc.identifier.bibliographicCitationJOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol.66(12) : 2791-2796, 2011-
dc.identifier.rimsid27463-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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