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Portal venous invasion: the single most independent risk factor for immediate postoperative recurrence of hepatocellular carcinoma

 Kang Kook Choi  ;  Sung Hoon Kim  ;  Kyung Sik Kim  ;  Jin Sub Choi  ;  Gi Hong Choi  ;  Jin Hong Lim  ;  Sae Byeol Choi 
 Journal of Gastroenterology and Hepatology, Vol.26(11) : 1646-1651, 2011 
Journal Title
 Journal of Gastroenterology and Hepatology 
Issue Date
BACKGROUND AND AIM: Despite improvements of treatment in hepatocellular carcinoma (HCC), the recurrence rate after curative hepatic resection still remains remarkably high. An immediate recurrence of HCC after surgery is frustrating. We tried to clarify risks of immediate postoperative recurrence of HCC; that is, within 4 months after curative hepatic resection. METHODS: A total of 167 patients with HCC underwent hepatic resection; 60 had immediate postoperative recurrences (IPR group), and 107 had disease-free survival for more than 5 years (DFS group). Variables were compared between the two groups. RESULTS: Univariate analysis showed the following variables were significant risk factors for immediate postoperative recurrence of HCC: male sex, elevated serum aspartate aminotransferase level, greater amount of blood loss, longer operation time, worse tumor differentiation, higher tumor node metastasis stage, and presence of any of the following: intrahepatic metastasis, tumor-rupture, portal venous invasion, or microvascular invasion. In multivariate analysis, only portal venous invasion was a significant risk factor (odds ratio=3.2, P=0.03, standard error=0.5, Logistic regression analysis). CONCLUSIONS: Portal venous invasion may be the most significant risk factor for immediate postoperative recurrence of HCC. However, accurate assessment of this risk factor may require histological examination, limiting its utility as a preoperative predictor. Further research is necessary to definitively identify preoperative predictors.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
김경식(Kim, Kyung Sik) ; 김성훈(Kim, Sung Hoon) ; 임진홍(Lim, Jin Hong) ; 최기홍(Choi, Gi Hong) ; 최진섭(Choi, Jin Sub)
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