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Urinary excretion of nephrin in patients with severe preeclampsia. Urinary nephrin in preeclampsia

Authors
 Ga Hyun Son  ;  Jeong Hyeon Kim  ;  Jung Hae Hwang  ;  Young Han Kim  ;  Yong Won Park  ;  Ja Young Kwon 
Citation
 Hypertension in Pregnancy, Vol.30(4) : 408-413, 2011 
Journal Title
 Hypertension in Pregnancy 
ISSN
 1064-1955 
Issue Date
2011
MeSH
Adult ; Case-Control Studies ; Female ; Humans ; Membrane Proteins/urine* ; Pre-Eclampsia/urine* ; Pregnancy ; Prenatal Diagnosis* ; Severity of Illness Index
Keywords
Urinary nephrin ; Severe preeclampsia
Abstract
OBJECTIVE: The objective of this study was to examine whether nephrin is present in the urine of patients with severe preeclampsia. METHODS: A total of 45 women were recruited for this study, and 25 of these patients had severe preeclampsia. Twenty gestational age-matched normotensive women without proteinuria served as a control group. Urine samples were collected close to delivery, typically ≤24 h before delivery. Western blot analysis was performed to assess the excretion of nephrin in urine. RESULTS: Nephrin was detected in all urine samples from all the women with severe preeclampsia but not in urine from normotensive controls. CONCLUSION: In pregnancy complicated by severe preeclampsia, urinary nephrin shedding, reflecting the damage in the glomerular slit diaphragm, was observed.
Full Text
http://informahealthcare.com/doi/abs/10.3109/10641955.2010.507841
DOI
10.3109/10641955.2010.507841
Appears in Collections:
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Kim, Young Han(김영한) ORCID logo https://orcid.org/0000-0003-0645-6028
Park, Yong Won(박용원)
Son, Ga Hyun(손가현)
Hwang, Jung Hae(황정혜)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94559
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