Urinary excretion of nephrin in patients with severe preeclampsia. Urinary nephrin in preeclampsia

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Authors: Ga Hyun Son ; Jeong Hyeon Kim ; Jung Hae Hwang ; Young Han Kim ; Yong Won Park ; Ja Young Kwon

MeSH: Adult ; Case-Control Studies ; Female ; Humans ; Membrane Proteins/urine* ; Pre-Eclampsia/urine* ; Pregnancy ; Prenatal Diagnosis* ; Severity of Illness Index

Abstract: OBJECTIVE: The objective of this study was to examine whether nephrin is present in the urine of patients with severe preeclampsia.

METHODS: A total of 45 women were recruited for this study, and 25 of these patients had severe preeclampsia. Twenty gestational age-matched normotensive women without proteinuria served as a control group. Urine samples were collected close to delivery, typically ≤24 h before delivery. Western blot analysis was performed to assess the excretion of nephrin in urine.

RESULTS: Nephrin was detected in all urine samples from all the women with severe preeclampsia but not in urine from normotensive controls.

CONCLUSION: In pregnancy complicated by severe preeclampsia, urinary nephrin shedding, reflecting the damage in the glomerular slit diaphragm, was observed.

Full Text: http://informahealthcare.com/doi/abs/10.3109/10641955.2010.507841

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

Yonsei Authors: Kwon, Ja Young(권자영) https://orcid.org/0000-0003-3009-6325
Kim, Young Han(김영한) https://orcid.org/0000-0003-0645-6028
Park, Yong Won(박용원)
Son, Ga Hyun(손가현)
Hwang, Jung Hae(황정혜)

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YUHSpace: Urinary excretion of nephrin in patients with severe preeclampsia. Urinary nephrin in preeclampsia