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Urinary excretion of nephrin in patients with severe preeclampsia. Urinary nephrin in preeclampsia

Authors
 Ga Hyun Son  ;  Jeong Hyeon Kim  ;  Ja Young Kwon  ;  Yong Won Park  ;  Young Han Kim  ;  Jung Hae Hwang 
Citation
 Hypertension in Pregnancy, Vol.30(4) : 408-413, 2011 
Journal Title
 Hypertension in Pregnancy 
ISSN
 1064-1955 
Issue Date
2011
Abstract
OBJECTIVE: The objective of this study was to examine whether nephrin is present in the urine of patients with severe preeclampsia. METHODS: A total of 45 women were recruited for this study, and 25 of these patients had severe preeclampsia. Twenty gestational age-matched normotensive women without proteinuria served as a control group. Urine samples were collected close to delivery, typically ≤24 h before delivery. Western blot analysis was performed to assess the excretion of nephrin in urine. RESULTS: Nephrin was detected in all urine samples from all the women with severe preeclampsia but not in urine from normotensive controls. CONCLUSION: In pregnancy complicated by severe preeclampsia, urinary nephrin shedding, reflecting the damage in the glomerular slit diaphragm, was observed.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94559
DOI
10.3109/10641955.2010.507841
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터)
Yonsei Authors
권자영(Kwon, Ja Young) ; 김영한(Kim, Young Han) ; 박용원(Park, Yong Won) ; 손가현(Son, Ga Hyun) ; 황정혜(Hwang, Jung Hae)
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Full Text
http://informahealthcare.com/doi/abs/10.3109/10641955.2010.507841
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