Cited 17 times in
Evaluation of automated serum des-gamma-carboxyprothrombin (DCP) assays for detecting hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | 김정호 | - |
dc.contributor.author | 김현숙 | - |
dc.contributor.author | 박용정 | - |
dc.date.accessioned | 2014-12-20T17:24:51Z | - |
dc.date.available | 2014-12-20T17:24:51Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0009-9120 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94557 | - |
dc.description.abstract | OBJECTIVES: We evaluated two new autoanalyzers, μTAS and Lumipulse for des-γ-carboxyprothrombin (DCP) assay. MATERIAL AND METHODS: Analytical performance was evaluated, and the upper reference limit of the 97.5th percentile for DCP was re-established using sera from 140 healthy individuals. DCP levels were determined by the two autoanalyzers and EIA in a total of 239 sera from HCC patients (n=120) and those without HCC (n=119). RESULTS: Total imprecision of the two automated assays was <5% CV. Analytical measurement ranges (AMRs) were verified to be linear. The new reference limits were 29.5 mAU/mL for μTAS and 35.0 mAU/mL for Lumipulse. There were proportional and constant biases between the results from the autoanalyzers and those from EIA. CONCLUSION: The two newly developed DCP assays showed high analytical performance, but re-establishment of reference limits would be necessary. The new analyzers could be useful for clinical laboratories because of convenience of operation and wide AMRs | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1464~1468 | - |
dc.relation.isPartOf | CLINICAL BIOCHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Automation, Laboratory* | - |
dc.subject.MESH | Biomarkers/blood* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/blood | - |
dc.subject.MESH | Carcinoma, Hepatocellular/diagnosis* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoassay/methods | - |
dc.subject.MESH | Immunoassay/standards | - |
dc.subject.MESH | Liver Neoplasms/blood | - |
dc.subject.MESH | Liver Neoplasms/diagnosis* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Protein Precursors/blood* | - |
dc.subject.MESH | Prothrombin | - |
dc.subject.MESH | Quality Control | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Reference Standards | - |
dc.subject.MESH | Reference Values | - |
dc.title | Evaluation of automated serum des-gamma-carboxyprothrombin (DCP) assays for detecting hepatocellular carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Jonghyeon Choi | - |
dc.contributor.googleauthor | Yongjung Park | - |
dc.contributor.googleauthor | Jeong-Ho Kim | - |
dc.contributor.googleauthor | Hyon-Suk Kim | - |
dc.identifier.doi | 10.1016/j.clinbiochem.2011.08.1144 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00903 | - |
dc.contributor.localId | A01582 | - |
dc.contributor.localId | A01117 | - |
dc.relation.journalcode | J00561 | - |
dc.identifier.eissn | 1873-2933 | - |
dc.identifier.pmid | 21939644 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0009912011026324 | - |
dc.subject.keyword | Des-γ-carboxyprothrombin (DCP) | - |
dc.subject.keyword | Hepatocellular carcinoma (HCC) | - |
dc.subject.keyword | Protein induced by vitamin K absence or antagonist-II (PIVKA-II) | - |
dc.subject.keyword | Automated analyzer | - |
dc.subject.keyword | Reference range | - |
dc.contributor.alternativeName | Kim, Jeong Ho | - |
dc.contributor.alternativeName | Kim, Hyon Suk | - |
dc.contributor.alternativeName | Park, Yong Jung | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Ho | - |
dc.contributor.affiliatedAuthor | Park, Yong Jung | - |
dc.contributor.affiliatedAuthor | Kim, Hyon Suk | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 44 | - |
dc.citation.number | 17-18 | - |
dc.citation.startPage | 1464 | - |
dc.citation.endPage | 1468 | - |
dc.identifier.bibliographicCitation | CLINICAL BIOCHEMISTRY, Vol.44(17-18) : 1464-1468, 2011 | - |
dc.identifier.rimsid | 27416 | - |
dc.type.rims | ART | - |
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