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근관 삼출액에서의 기질금속단백분해효소-8과 substance P의 수준에 관한 연구

Other Titles
 Matrix metalloproteinase-8 and substance P levels in root canal exudates of nonvital teeth 
 신수정  ;  이우철  ;  이재일  ;  백승호  ;  금기연  ;  손원준  ;  배광식 
 Journal of Korean Academy of Operative Dentistry (대한치과보존학회지), Vol.36(3) : 196-202, 2011 
Journal Title
Journal of Korean Academy of Operative Dentistry(대한치과보존학회지)
Issue Date
Adult ; Female ; Follow-Up Studies ; Gingival Crevicular Fluid/chemistry* ; Humans ; Inflammation Mediators/analysis ; Male ; Matrix Metalloproteinase 8/analysis* ; Neurotransmitter Agents/analysis* ; Pain Measurement ; Periapical Periodontitis/metabolism ; Prospective Studies ; Root Canal Irrigants/therapeutic use ; Root Canal Obturation/methods ; Root Canal Preparation/instrumentation ; Root Canal Therapy* ; Sodium Hypochlorite/therapeutic use ; Substance P/analysis* ; Tooth, Nonvital/metabolism ; Tooth, Nonvital/therapy* ; Toothache/metabolism
OBJECTIVES: The aim of this study was to investigate levels of matrix metalloproteinase-8 (MMP-8) and substance P (SP) in root canal exudates during root canal treatment (RCT) of nonvital, painful teeth. MATERIALS AND METHODS: Patients scheduled for nonsurgical RCT were prospectively selected; the study was performed after obtaining informed consent from the patients and was approved by the Institutional Review Board for Clinical Research of Gangnam Severance Hospital, Yonsei University (3-2008-0118). Canal exudates samples were collected using sterilized paper points from teeth scheduled for RCT across three different time periods. MMP-8 and SP levels were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using a mixed model analysis and the Pearson correlation analysis (p < 0.05). RESULTS: MMP-8 and SP levels in GCF were decreased during RCT (p < 0.0001), and they showed a weak positive correlation to each other (p < 0.05). Patients'subjective pain levels and the response from percussion test were significantly related to SP level. CONCLUSIONS: This study demonstrated that periradicular inflammation endodontic origin can elevate SP and MMP-8 levels in root canal exudates. Interestingly, SP level of canal exudates showed a possibility of being used as an indicator of pain due to periapical pathosis
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Conservative Dentistry (보존과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Su Jung(신수정) ORCID logo https://orcid.org/0000-0001-5795-3919
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