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Effect of Oral Supplementation with Branched-chain Amino Acid (BCAA) during Radiotherapy in Patients with Hepatocellular Carcinoma: A Double-Blind Randomized Study.

DC Field Value Language
dc.contributor.author성진실-
dc.contributor.author유세환-
dc.contributor.author이유미-
dc.contributor.author이익재-
dc.date.accessioned2014-12-20T17:24:12Z-
dc.date.available2014-12-20T17:24:12Z-
dc.date.issued2011-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/94536-
dc.description.abstractPURPOSE: The present study evaluated whether oral supplementation with a branched-chain amino acid (BCAA) improves the biochemical and amino acid profiles of liver tumor patients undergoing radiotherapy. MATERIALS AND METHODS: Patients were randomly assigned to one of 2 groups: a group given oral supplementation with BCAA granules (LIVACT granules; Samil Pharm Co., Korea, each granule containing L-isoleucine 952 mg, L-leucine 1,904 mg, and L-valine 1,144 mg) during radiotherapy, or a placebo group. Physical and biochemical examinations and measurements, including subjective symptoms, Child-Pugh class, body mass index, plasma albumin concentration, and plasma amino acid profiles were monitored. RESULTS: Fifty were enrolled between November 2005 and November 2006. We also analyzed data from 37 hepatocellular carcinoma (HCC) patients in order to evaluate a more homogenous group. The two groups of patients were comparable in terms of age, gender, Child-Pugh score, and underlying hepatitis virus type. Serum albumin, total protein, liver enzymes, and cholesterol showed a tendency to increase in the BCAA group. In this group, the percentage of cases that reverted to normal serum albumin levels between 3 and 10 weeks after administration of BCAA was significantly higher (41.18%) than in the placebo group (p=0.043). CONCLUSION: Oral supplementation with a BCAA preparation seems to help HCC patients undergoing radiotherapy by increasing the BCAA concentration.-
dc.description.statementOfResponsibilityopen-
dc.format.extent24~31-
dc.relation.isPartOfCANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffect of Oral Supplementation with Branched-chain Amino Acid (BCAA) during Radiotherapy in Patients with Hepatocellular Carcinoma: A Double-Blind Randomized Study.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorIk Jae Lee-
dc.contributor.googleauthorJinsil Seong-
dc.contributor.googleauthorJung Im Bae-
dc.contributor.googleauthorSei Hwan You-
dc.contributor.googleauthorYumie Rhee-
dc.contributor.googleauthorJong Ho Lee-
dc.identifier.doi10.4143/crt.2011.43.1.24-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01956-
dc.contributor.localIdA02474-
dc.contributor.localIdA03012-
dc.contributor.localIdA03055-
dc.relation.journalcodeJ00453-
dc.identifier.eissn2005-9256-
dc.identifier.pmid21509160-
dc.subject.keywordBranched-chain amino acids-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordRadiotherapy-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.alternativeNameYou, Sei Hwan-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameLee, Ik Jae-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.contributor.affiliatedAuthorYou, Sei Hwan-
dc.contributor.affiliatedAuthorRhee, Yumie-
dc.contributor.affiliatedAuthorLee, Ik Jae-
dc.rights.accessRightsfree-
dc.citation.volume43-
dc.citation.number1-
dc.citation.startPage24-
dc.citation.endPage31-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, Vol.43(1) : 24-31, 2011-
dc.identifier.rimsid27396-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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