Cited 49 times in
Treatment of the elderly when cure is the goal: the influence of age on treatment selection and efficacy for stage III non-small cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | 조병철 | - |
dc.date.accessioned | 2014-12-20T17:24:08Z | - |
dc.date.available | 2014-12-20T17:24:08Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1556-0864 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94534 | - |
dc.description.abstract | BACKGROUND: : Treatment of elderly patients with stage III NSCLC is controversial. Limited data exist, as the elderly are underrepresented in clinical trials. METHODS: : After ethics approval, we performed a retrospective review of 1372 stage III NSCLC patients treated at our institution during the period 1997-2007. Patients with malignant effusions and microscopic N2 discovered only postoperatively were excluded, leaving 740 who were classified by treatment plan: palliative (palliative chemotherapy or radiation [≤40 Gy]); nonsurgical multimodality (>40 Gy radiation ± chemotherapy); or surgical multimodality (chemotherapy, radiation, and surgery). Demographics, treatment, toxicity, and survival were analyzed by age, 0 to 65 years, n = 384; 66 to 75 years, n = 256; 76+ years, n = 100, and compared using log-rank, univariate, and multivariate statistical tests. RESULTS: : Patients older than 65 years were more likely to have poor performance status (p < 0.0001), multiple comorbidities (p < 0.0001), and to receive palliative therapy only (p < 0.0001). Older and younger patients treated with curative intent with nonsurgical bimodality therapy or trimodality therapy including surgery had similar rates of grade 3/4 toxicity (0-65 years, 39%; 66-75 years, 43%; 76+ years, 5%; p = 0.18) and toxic death (0-65 years, 4%; 66-75 years, 4%; 76+ years, 0%; p = 0.76). Survival was worse with increasing age (p < 0.0001), likely due to greater use of palliative treatment in the elderly. When survival was analyzed for patients treated with curative intent, there was no difference between age groups for nonsurgical (p = 0.32) or surgical (p = 0.53) therapy. CONCLUSION: : In select fit elderly patients, combined modality therapy is tolerable and is associated with survival similar to that of younger patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 537~544 | - |
dc.relation.isPartOf | JOURNAL OF THORACIC ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/therapy | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antineoplastic Agents/therapeutic use* | - |
dc.subject.MESH | Carcinoma, Large Cell/therapy | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/therapy* | - |
dc.subject.MESH | Carcinoma, Squamous Cell/therapy | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Comorbidity | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung Neoplasms/therapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Palliative Care | - |
dc.subject.MESH | Pneumonectomy* | - |
dc.subject.MESH | Radiotherapy Dosage | - |
dc.subject.MESH | Research Design* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Treatment of the elderly when cure is the goal: the influence of age on treatment selection and efficacy for stage III non-small cell lung cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Linda E. Coate | - |
dc.contributor.googleauthor | Christine Massey | - |
dc.contributor.googleauthor | Andrew Hope | - |
dc.contributor.googleauthor | Adrian Sacher | - |
dc.contributor.googleauthor | Katherine Barrett | - |
dc.contributor.googleauthor | Andrew Pierre | - |
dc.contributor.googleauthor | Natasha Leighl | - |
dc.contributor.googleauthor | Anthony Brade | - |
dc.contributor.googleauthor | Marc de Perrot | - |
dc.contributor.googleauthor | Tom Waddell | - |
dc.contributor.googleauthor | Geoffrey Liu | - |
dc.contributor.googleauthor | Ronald Feld | - |
dc.contributor.googleauthor | Ronald Burkes | - |
dc.contributor.googleauthor | B. C. John Cho | - |
dc.contributor.googleauthor | Gail Darling | - |
dc.contributor.googleauthor | Alexander Sun | - |
dc.contributor.googleauthor | Shaf Keshavjee | - |
dc.contributor.googleauthor | Andrea Bezjak | - |
dc.contributor.googleauthor | Frances A. Shepherd | - |
dc.identifier.doi | 10.1097/JTO.0b013e31820b8b9b | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03822 | - |
dc.relation.journalcode | J01909 | - |
dc.identifier.eissn | 1556-1380 | - |
dc.identifier.pmid | 21258243 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=01243894-201103000-00019&LSLINK=80&D=ovft | - |
dc.subject.keyword | Locally advanced | - |
dc.subject.keyword | Non-small cell lung cancer | - |
dc.subject.keyword | Elderly | - |
dc.subject.keyword | Combined modality treatment | - |
dc.subject.keyword | Trimodality | - |
dc.subject.keyword | Stage III NSCLC | - |
dc.contributor.alternativeName | Cho, Byoung Chul | - |
dc.contributor.affiliatedAuthor | Cho, Byoung Chul | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 6 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 537 | - |
dc.citation.endPage | 544 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THORACIC ONCOLOGY, Vol.6(3) : 537-544, 2011 | - |
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