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Gastroduodenal complications after concurrent chemoradiation therapy in patients with hepatocellular carcinoma: endoscopic findings and risk factors

DC Field Value Language
dc.contributor.author전재윤-
dc.contributor.author한광협-
dc.contributor.author김도영-
dc.contributor.author김범경-
dc.contributor.author김승업-
dc.contributor.author박준용-
dc.contributor.author성진실-
dc.contributor.author신성관-
dc.contributor.author안상훈-
dc.contributor.author전영은-
dc.date.accessioned2014-12-20T17:22:38Z-
dc.date.available2014-12-20T17:22:38Z-
dc.date.issued2011-
dc.identifier.issn0360-3016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/94486-
dc.description.abstractPURPOSE: Concurrent chemoradiation therapy (CCRT) is useful in advanced hepatocellular carcinoma (HCC), but little is known about radiation-induced gastroduodenal complications following therapy. To determine risk factors, we investigated the prevalence and patterns of gastroduodenal complications following CCRT using endoscopy. METHODS AND MATERIALS: Enrolled in the study were 123 patients treated with CCRT for unresectable HCC between January 1998 and December 2005. Radiation-induced gastroduodenal complications were defined as radiation gastritis/duodenitis, radiation gastric/duodenal ulcer, or other gastroduodenal toxicity associated with radiation, based on Common Terminology Criteria for Adverse Events (CTCAE 3.0). Serious gastroduodenal complications were defined as events occurring within 12 months from completion of CCRT, those requiring prompt therapeutic intervention, or symptoms equivalent to Grade 3 or 4 radiation-related gastroduodenal toxicity, including nausea or vomiting, based on CTCAE 3.0. RESULTS: A month after completion of CCRT, 65 (52.8%) patients displayed endoscopic evidence of radiation-induced gastroduodenal complications. Radiation gastric and duodenal ulcers were found in 32 (26.0%) and 20 (16.3%) patients, respectively; radiation gastritis and duodenitis were found in 50 (40.7%) and 42 (34.1%) patients, respectively. Radiation-related bleeding was observed in 13 patients (10.6%). Serious gastroduodenal complications occurred in 18 patients (14.6%) and were significantly more frequent in patients with liver cirrhosis than in those without cirrhosis (p=0.043). There were no radiation-related deaths. CONCLUSIONS: Endoscopically detectable radiation-induced gastroduodenal complications were common in HCC following CCRT. Although serious complications were uncommon, the frequency was higher in patients with liver cirrhosis; thus, these patients should be closely monitored when receiving CCRT.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1343~1351-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAntimetabolites, Antineoplastic/administration & dosage-
dc.subject.MESHCarcinoma, Hepatocellular/therapy*-
dc.subject.MESHChemoradiotherapy/adverse effects*-
dc.subject.MESHChemoradiotherapy/methods-
dc.subject.MESHDuodenal Ulcer/diagnosis-
dc.subject.MESHDuodenal Ulcer/epidemiology-
dc.subject.MESHDuodenitis/diagnosis-
dc.subject.MESHDuodenitis/epidemiology-
dc.subject.MESHDuodenum/radiation effects*-
dc.subject.MESHEndoscopy, Gastrointestinal*-
dc.subject.MESHFemale-
dc.subject.MESHFluorouracil/administration & dosage-
dc.subject.MESHGastritis/diagnosis-
dc.subject.MESHGastritis/epidemiology-
dc.subject.MESHGastrointestinal Hemorrhage/etiology-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms/therapy*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNausea/epidemiology-
dc.subject.MESHNausea/etiology-
dc.subject.MESHPrevalence-
dc.subject.MESHProspective Studies-
dc.subject.MESHRadiation Injuries/diagnosis*-
dc.subject.MESHRadiation Injuries/epidemiology-
dc.subject.MESHRadiotherapy Dosage-
dc.subject.MESHRisk Factors-
dc.subject.MESHStomach/radiation effects*-
dc.subject.MESHStomach Ulcer/diagnosis-
dc.subject.MESHStomach Ulcer/epidemiology-
dc.subject.MESHVomiting/epidemiology-
dc.subject.MESHVomiting/etiology-
dc.titleGastroduodenal complications after concurrent chemoradiation therapy in patients with hepatocellular carcinoma: endoscopic findings and risk factors-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorYoung Eun Chon-
dc.contributor.googleauthorJinsil Seong-
dc.contributor.googleauthorBeom Kyung Kim-
dc.contributor.googleauthorJihye Cha-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorChae Yoon Chon-
dc.contributor.googleauthorSung Kwan Shin-
dc.contributor.googleauthorDo Young Kim-
dc.identifier.doi10.1016/j.ijrobp.2010.07.1986-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04268-
dc.contributor.localIdA00487-
dc.contributor.localIdA00654-
dc.contributor.localIdA01675-
dc.contributor.localIdA01956-
dc.contributor.localIdA02112-
dc.contributor.localIdA02226-
dc.contributor.localIdA03532-
dc.contributor.localIdA03544-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ01157-
dc.identifier.eissn1879-355X-
dc.identifier.pmid20934268-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0360301610030336-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordRadiotherapy-
dc.subject.keywordConcurrent chemoradiation therapy-
dc.subject.keywordEndoscopy-
dc.subject.keywordComplication-
dc.contributor.alternativeNameChon, Chae Yoon-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Beom Kyung-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.alternativeNameShin, Sung Kwan-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameChon, Young Eun-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Beom Kyung-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.contributor.affiliatedAuthorShin, Sung Kwan-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorChon, Young Eun-
dc.contributor.affiliatedAuthorChon, Chae Yoon-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.rights.accessRightsnot free-
dc.citation.volume81-
dc.citation.number5-
dc.citation.startPage1343-
dc.citation.endPage1351-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.81(5) : 1343-1351, 2011-
dc.identifier.rimsid27361-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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