3 718

Cited 13 times in

Relation of homocysteinemia to contrast-induced nephropathy in patients undergoing percutaneous coronary intervention.

DC Field Value Language
dc.contributor.author강신욱-
dc.contributor.author고영국-
dc.contributor.author김병극-
dc.contributor.author김승준-
dc.contributor.author김중선-
dc.contributor.author유태현-
dc.contributor.author장양수-
dc.contributor.author최규헌-
dc.contributor.author최동훈-
dc.contributor.author한승혁-
dc.contributor.author홍명기-
dc.date.accessioned2014-12-20T17:21:59Z-
dc.date.available2014-12-20T17:21:59Z-
dc.date.issued2011-
dc.identifier.issn0002-9149-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/94466-
dc.description.abstractHyperhomocysteinemia induces oxidative stress and endothelial dysfunction, which share the proposed pathophysiologic mechanisms of contrast-induced nephropathy (CIN). However, no study has investigated the relation between hyperhomocysteinemia and CIN. The aim of the present study was to evaluate the effects of hyperhomocysteinemia on CIN in patients undergoing percutaneous coronary intervention. This was an observational cohort study that included 572 patients who underwent percutaneous coronary intervention. CIN was defined as an absolute ≥0.5 mg/dl or a relative ≥25% increase in the serum creatinine level at 48 hours after the procedure. The incidence of CIN was significantly greater in patients in the third homocysteine tertile (from lowest to highest, 4.7%, 7.3%, and 24.2%, p <0.001). Furthermore, the homocysteine levels were significantly greater in patients with CIN than in those without CIN (16.9 ± 4.9 vs 13.5 ± 4.2 μmol/L, p <0.001). In multiple logistic regression models, hyperhomocysteinemia was an independent risk factor for CIN (per the SD change in the plasma homocysteine level [4.44 μmol/L], odds ratio 1.70, 95% confidence interval 1.07 to 2.71, p = 0.025) after adjusting for major risk factors such as age, diabetes, and baseline cardiac and renal function. In subgroup analyses according to diabetes, acute coronary syndrome, or baseline estimated glomerular filtration rate, significant, graded associations were found between the homocysteine level and the incidence of CIN. In conclusion, hyperhomocysteinemia is independently associated with a greater risk of CIN in patients undergoing percutaneous coronary intervention.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1086~1091-
dc.relation.isPartOfAMERICAN JOURNAL OF CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAngioplasty, Balloon, Coronary*-
dc.subject.MESHContrast Media/adverse effects*-
dc.subject.MESHCoronary Angiography/adverse effects-
dc.subject.MESHCoronary Angiography/methods-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGlomerular Filtration Rate/drug effects-
dc.subject.MESHHomocysteine/blood*-
dc.subject.MESHHumans-
dc.subject.MESHHyperhomocysteinemia/blood-
dc.subject.MESHHyperhomocysteinemia/chemically induced*-
dc.subject.MESHKidney Diseases/blood-
dc.subject.MESHKidney Diseases/chemically induced*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMyocardial Infarction/blood-
dc.subject.MESHMyocardial Infarction/diagnosis*-
dc.subject.MESHMyocardial Infarction/therapy-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTime Factors-
dc.subject.MESHTriiodobenzoic Acids/adverse effects-
dc.titleRelation of homocysteinemia to contrast-induced nephropathy in patients undergoing percutaneous coronary intervention.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSeung Jun Kim-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorJung-Sun Kim-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorByung-Keuk Kim-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorMyeong-Ki Hong-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorKyu Hun Choi-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.identifier.doi10.1016/j.amjcard.2011.06.010-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00053-
dc.contributor.localIdA00127-
dc.contributor.localIdA00493-
dc.contributor.localIdA00961-
dc.contributor.localIdA02526-
dc.contributor.localIdA03448-
dc.contributor.localIdA04043-
dc.contributor.localIdA04053-
dc.contributor.localIdA04304-
dc.contributor.localIdA04391-
dc.contributor.localIdA00659-
dc.relation.journalcodeJ00071-
dc.identifier.eissn1879-1913-
dc.identifier.pmid21791335-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0002914911019977-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.alternativeNameKim, Byeong Keuk-
dc.contributor.alternativeNameKim, Seung Jun-
dc.contributor.alternativeNameKim, Jung Sun-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChoi, Kyu Hun-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameHong, Myeong Ki-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorKo, Young Guk-
dc.contributor.affiliatedAuthorKim, Byeong Keuk-
dc.contributor.affiliatedAuthorKim, Jung Sun-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChoi, Kyu Hun-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorHong, Myeong Ki-
dc.contributor.affiliatedAuthorKim, Seung Jun-
dc.rights.accessRightsnot free-
dc.citation.volume108-
dc.citation.number8-
dc.citation.startPage1086-
dc.citation.endPage1091-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF CARDIOLOGY, Vol.108(8) : 1086-1091, 2011-
dc.identifier.rimsid27350-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.