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Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling

Authors
 Ji-Hwan Ryu  ;  Seung Chul Shin  ;  Won-Jae Lee  ;  Joo-Heon Yoon  ;  Kyung-Ah Lee  ;  Aeri C. Kim  ;  Boram Kim  ;  Hyejin You  ;  Sung-Hee Kim 
Citation
 Science, Vol.334(6056) : 670-674, 2011 
Journal Title
 Science 
ISSN
 0036-8075 
Issue Date
2011
Abstract
The symbiotic microbiota profoundly affect many aspects of host physiology; however, the molecular mechanisms underlying host-microbe cross-talk are largely unknown. Here, we show that the pyrroloquinoline quinone-dependent alcohol dehydrogenase (PQQ-ADH) activity of a commensal bacterium, Acetobacter pomorum, modulates insulin/insulin-like growth factor signaling (IIS) in Drosophila to regulate host homeostatic programs controlling developmental rate, body size, energy metabolism, and intestinal stem cell activity. Germ-free animals monoassociated with PQQ-ADH mutant bacteria displayed severe deregulation of developmental and metabolic homeostasis. Importantly, these defects were reversed by enhancing host IIS or by supplementing the diet with acetic acid, the metabolic product of PQQ-ADH
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94449
DOI
10.1126/science.1212782
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Research Center for Human Natural Defense System (생체방어연구센터)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실)
Yonsei Authors
유지환(Ryu, Ji Hwan) ; 윤주헌(Yoon, Joo Heon)
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