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Trends in antimicrobial resistance of Neisseria gonorrhoeae isolated from Korean patients from 2000 to 2006

DC FieldValueLanguage
dc.contributor.author용동은-
dc.contributor.author이경원-
dc.contributor.author정석훈-
dc.contributor.author정윤섭-
dc.date.accessioned2014-12-20T17:20:58Z-
dc.date.available2014-12-20T17:20:58Z-
dc.date.issued2011-
dc.identifier.issn0148-5717-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/94433-
dc.description.abstractBACKGROUND: The recent emergence and spread of antimicrobial-resistant Neisseria gonorrhoeae has compromised treatment and control of gonorrhea. We determined recent trends in antimicrobial susceptibility of the isolates, analyzed recent use of antigonococcal agents, and investigated the relationship between fluoroquinolone nonsusceptibility and amino acid substitutions within the fluoroquinolone resistance-determining regions in Korea. METHODS: The antimicrobial susceptibilities of 977 isolates of N. gonorrhoeae collected from 2000 to 2006 in Korea were determined with penicillin, ceftriaxone, spectinomycin, tetracycline, and ciprofloxacin disks. Some of the randomly selected isolates were tested by the Clinical and Laboratory Standards Institute agar dilution method, to determine subtle changes in susceptibility to the above antibiotics and cefixime. β-lactamase was detected using a cefinase disk. RESULTS: All of the isolates exhibited plasmid- or chromosomally mediated resistance to penicillin; however, the proportions of penicillinase-producing N. gonorrhoeae decreased rapidly from 64% in 2000 to 21% in 2006. All isolates were susceptible to third-generation cephalosporins, except for 1 isolate that was not susceptible to cefixime. The proportion of ciprofloxacin-resistant isolates increased from 26% in 2000 to 83% in 2006. Of 7 substitution types, 5 (Ser-91-Phe in Gyrase A (GyrA), Ser-87-Arg in ParC subunit of topoisomerase IV (ParC); Ser-91-Phe and Asp-95-Ala in GyrA, and Ser-87-Asn in ParC; Ser-91-Phe and Asp-95-Gly in GyrA, and Asp-86-Asn in ParC; Ser-91-Tyr in GyrA; Ser-91-Phe in GyrA, and Asp-86-Asn in ParC) were new ones not identified in our 2004 study. All isolates were susceptible to spectinomycin. About half of the patients in our current study (52.6%-58.1%, depending on the year) received spectinomycin treatment. Majorities were resistant to tetracycline, and the rate of highly tetracycline-resistant N. gonorrhoeae increased from 3% in 2000 to 9% in 2006. CONCLUSIONS: The incidence of penicillinase-producing N. gonorrhoeae declined significantly, but none of the isolates were susceptible to penicillin G. All isolates were susceptible to spectinomycin, in contrast majority were resistant to tetracycline. Inappropriate use of fluoroquinolone was frequent. The minimum inhibitory concentrations of ceftriaxone were within the susceptible range for all isolates, but those of cefixime were slightly higher, and it was 0.5 μg/mL (nonsusceptible) for 1 isolate-
dc.description.statementOfResponsibilityopen-
dc.format.extent1082~1086-
dc.relation.isPartOfSEXUALLY TRANSMITTED DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnti-Bacterial Agents/pharmacology*-
dc.subject.MESHDNA Gyrase/genetics-
dc.subject.MESHDNA Topoisomerase IV/genetics-
dc.subject.MESHDrug Resistance, Bacterial*-
dc.subject.MESHFemale-
dc.subject.MESHGonorrhea/drug therapy-
dc.subject.MESHGonorrhea/epidemiology*-
dc.subject.MESHGonorrhea/microbiology-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMicrobial Sensitivity Tests-
dc.subject.MESHNeisseria gonorrhoeae/drug effects*-
dc.subject.MESHNeisseria gonorrhoeae/isolation & purification-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHSequence Analysis, DNA-
dc.subject.MESHSex Work-
dc.subject.MESHUrethritis/drug therapy-
dc.subject.MESHUrethritis/epidemiology-
dc.subject.MESHUrethritis/microbiology-
dc.titleTrends in antimicrobial resistance of Neisseria gonorrhoeae isolated from Korean patients from 2000 to 2006-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorHyukmin Lee-
dc.contributor.googleauthorSeong Geun Hong-
dc.contributor.googleauthorYounghee Soe-
dc.contributor.googleauthorDongeun Yong-
dc.contributor.googleauthorSeok Hoon Jeong-
dc.contributor.googleauthorKyungwon Lee-
dc.contributor.googleauthorYunsop Chong-
dc.identifier.doi10.1097/OLQ.0b013e31822e60a4-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02423-
dc.contributor.localIdA02649-
dc.contributor.localIdA03619-
dc.contributor.localIdA03679-
dc.relation.journalcodeJ02656-
dc.identifier.eissn1537-4521-
dc.identifier.pmid21992988-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00007435-201111000-00017&LSLINK=80&D=ovft-
dc.contributor.alternativeNameYong, Dong Eun-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.alternativeNameJeong, Seok Hoon-
dc.contributor.alternativeNameChong, Yun Sop-
dc.contributor.affiliatedAuthorYong, Dong Eun-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorJeong, Seok Hoon-
dc.contributor.affiliatedAuthorChong, Yun Sop-
dc.rights.accessRightsnot free-
dc.citation.volume38-
dc.citation.number11-
dc.citation.startPage1082-
dc.citation.endPage1086-
dc.identifier.bibliographicCitationSEXUALLY TRANSMITTED DISEASES, Vol.38(11) : 1082-1086, 2011-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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