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Localization of ictal onset zones in Lennox-Gastaut syndrome using directional connectivity analysis of intracranial electroencephalography

Authors
 Young-Jin Jung  ;  Hoon-Chul Kang  ;  Keom-Ok Choi  ;  Joon Soo Lee  ;  Dong-Seok Kim  ;  Jae-Hyun Cho  ;  Shin-Hye Kim  ;  Chang-Hwan Im  ;  Heung Dong Kim 
Citation
 SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, Vol.20(6) : 449-457, 2011 
Journal Title
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
ISSN
 1059-1311 
Issue Date
2011
MeSH
Algorithms ; Child, Preschool ; Data Interpretation, Statistical ; Drug Resistance ; Electrodes, Implanted ; Electroencephalography* ; Fourier Analysis ; Humans ; Image Processing, Computer-Assisted ; Intellectual Disability/complications ; Intellectual Disability/diagnosis ; Intellectual Disability/physiopathology* ; Intellectual Disability/surgery ; Intelligence Tests ; Lennox Gastaut Syndrome ; Magnetic Resonance Imaging ; Male ; Neurosurgical Procedures ; Positron-Emission Tomography ; Seizures/diagnosis ; Seizures/physiopathology* ; Seizures/surgery ; Spasms, Infantile/diagnosis ; Spasms, Infantile/physiopathology* ; Spasms, Infantile/surgery ; Tomography, Emission-Computed, Single-Photon ; Treatment Outcome
Keywords
Ictal onset zone ; Lennox-Gastaut syndrome (LGS) ; Directional connectivity analysis ; Directed transfer function (DTF) ; Intracranial electroencephalography (iEEG) ; Ictal epileptiform activity
Abstract
INTRODUCTION: Neuroscientists are becoming interested in the application of computational EEG analysis to the identification of ictal onset zones; however, most studies have focused on the localization of ictal onset zones in focal epilepsy. The present study aimed to estimate the ictal onset zone of Lennox-Gastaut syndrome (LGS) with bilaterally synchronous epileptiform discharges from intracranial electroencephalography (iEEG) recordings using directional connectivity analysis.

METHODS: We analyzed ictal iEEG data acquired from three LGS patients who underwent epileptic surgery with favorable surgical outcomes. To identify the ictal onset zones, we estimated the functional directional connectivity network among the intracerebral electrodes using the directed transfer function (DTF) method.

RESULTS: The analysis results demonstrated that areas with high average outflow values corresponded well with the surgical resection areas identified using electrophysiologic data and conventional neuroimaging modalities.

DISCUSSIONS: Our results suggest that the DTF analysis can be a useful auxiliary tool for determining surgical resection areas prior to epilepsy surgery in LGS patients. This is the first research article demonstrating that directional connectivity analysis of iEEG recording data can be used for delineating surgical resection areas in generalized epilepsy patients who need surgical treatment.
Full Text
http://www.sciencedirect.com/science/article/pii/S1059131111000483
DOI
10.1016/j.seizure.2011.02.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hoon Chul(강훈철) ORCID logo https://orcid.org/0000-0002-3659-8847
Kim, Dong Seok(김동석)
Kim, Shin Hye(김신혜)
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
Lee, Joon Soo(이준수) ORCID logo https://orcid.org/0000-0001-9036-9343
Choi, Keom Ok(최금옥)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94423
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