4 123

Cited 22 times in

Localization of ictal onset zones in Lennox-Gastaut syndrome using directional connectivity analysis of intracranial electroencephalography

 Young-Jin Jung  ;  Hoon-Chul Kang  ;  Heung Dong Kim  ;  Chang-Hwan Im  ;  Shin-Hye Kim  ;  Jae-Hyun Cho  ;  Dong-Seok Kim  ;  Joon Soo Lee  ;  Keom-Ok Choi 
 Seizure - European Journal of Epilepsy, Vol.20(6) : 449-457, 2011 
Journal Title
 Seizure - European Journal of Epilepsy 
Issue Date
INTRODUCTION: Neuroscientists are becoming interested in the application of computational EEG analysis to the identification of ictal onset zones; however, most studies have focused on the localization of ictal onset zones in focal epilepsy. The present study aimed to estimate the ictal onset zone of Lennox-Gastaut syndrome (LGS) with bilaterally synchronous epileptiform discharges from intracranial electroencephalography (iEEG) recordings using directional connectivity analysis. METHODS: We analyzed ictal iEEG data acquired from three LGS patients who underwent epileptic surgery with favorable surgical outcomes. To identify the ictal onset zones, we estimated the functional directional connectivity network among the intracerebral electrodes using the directed transfer function (DTF) method. RESULTS: The analysis results demonstrated that areas with high average outflow values corresponded well with the surgical resection areas identified using electrophysiologic data and conventional neuroimaging modalities. DISCUSSIONS: Our results suggest that the DTF analysis can be a useful auxiliary tool for determining surgical resection areas prior to epilepsy surgery in LGS patients. This is the first research article demonstrating that directional connectivity analysis of iEEG recording data can be used for delineating surgical resection areas in generalized epilepsy patients who need surgical treatment.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
Yonsei Authors
강훈철(Kang, Hoon Chul) ; 김동석(Kim, Dong Seok) ; 김신혜(Kim, Shin Hye) ; 김흥동(Kim, Heung Dong) ; 이준수(Lee, Joon Soo) ; 최금옥(Choi, Keom Ok)
사서에게 알리기
Full Text
RIS (EndNote)
XLS (Excel)


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.