Cited 151 times in
Effect of single recombinant human erythropoietin injection on transfusion requirements in preoperatively anemic patients undergoing valvular heart surgery.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 곽영란 | - |
dc.contributor.author | 김종찬 | - |
dc.contributor.author | 심재광 | - |
dc.contributor.author | 유영철 | - |
dc.contributor.author | 조윤이 | - |
dc.date.accessioned | 2014-12-20T17:19:19Z | - |
dc.date.available | 2014-12-20T17:19:19Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0003-3022 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94380 | - |
dc.description.abstract | BACKGROUND: The authors investigated the effect of a single preoperative bolus of erythropoietin on perioperative transfusion requirement and erythropoiesis in patients with preoperative anemia undergoing valvular heart surgery. METHODS: In this prospective, single-site, single-blinded, randomized, and parallel-arm controlled trial, 74 patients with preoperative anemia were randomly allocated to either the erythropoietin or the control group. The erythropoietin group received 500 IU/kg erythropoietin and 200 mg iron sucrose intravenously 1 day before the surgery. The control group received an equivalent volume of normal saline. The primary endpoint was transfusion requirement assessed during the surgery and for 4 days postoperatively. Reticulocyte count and iron profiles were measured serially and compared preoperatively and on postoperative days 1, 2, 4, and 7. RESULTS: Transfusion occurred in 32 patients (86%) of the control group versus 22 patients (59%) of the erythropoietin group (P = 0.009). The mean number of units of packed erythrocytes transfused per patient during the surgery and for 4 postoperative days (mean ± SD) was also significantly decreased in the erythropoietin group compared with the control group (3.3 ± 2.2 vs.. 1.0 ± 1.1 units/patient, P = 0.001). The reticulocyte count was significantly greater in the erythropoietin group at postoperative days 4 (P = 0.001) and 7 (P = 0.001). CONCLUSIONS: A single intravenous administration of erythropoietin and an iron supplement 1 day before surgery significantly reduced the perioperative transfusion requirement in anemic patients undergoing valvular heart surgery, implicating its potential role as a blood conservation strategy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 929~937 | - |
dc.relation.isPartOf | ANESTHESIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anemia/drug therapy* | - |
dc.subject.MESH | BloodTransfusion* | - |
dc.subject.MESH | Erythropoietin/therapeutic use* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | HeartValves/surgery* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Injections | - |
dc.subject.MESH | Iron/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Preoperative Care | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | RecombinantProteins/therapeutic use | - |
dc.subject.MESH | Single-Blind Method | - |
dc.title | Effect of single recombinant human erythropoietin injection on transfusion requirements in preoperatively anemic patients undergoing valvular heart surgery. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Young-Chul Yoo | - |
dc.contributor.googleauthor | Jae-Kwang Shim | - |
dc.contributor.googleauthor | Jong-Chan Kim | - |
dc.contributor.googleauthor | Youn-Yi Jo | - |
dc.contributor.googleauthor | Jong-Hoon Lee | - |
dc.contributor.googleauthor | Young-Lan Kwak | - |
dc.identifier.doi | 10.1097/ALN.0b013e318232004b | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A02205 | - |
dc.contributor.localId | A02484 | - |
dc.contributor.localId | A03873 | - |
dc.contributor.localId | A00929 | - |
dc.relation.journalcode | J00146 | - |
dc.identifier.eissn | 1528-1175 | - |
dc.identifier.pmid | 22027622 | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.alternativeName | Kim, Jong Chan | - |
dc.contributor.alternativeName | Shim, Jae Kwang | - |
dc.contributor.alternativeName | Yoo, Young Chul | - |
dc.contributor.alternativeName | Jo, Youn Yi | - |
dc.contributor.affiliatedAuthor | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | Shim, Jae Kwang | - |
dc.contributor.affiliatedAuthor | Yoo, Young Chul | - |
dc.contributor.affiliatedAuthor | Jo, Youn Yi | - |
dc.contributor.affiliatedAuthor | Kim, Jong Chan | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 115 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 929 | - |
dc.citation.endPage | 937 | - |
dc.identifier.bibliographicCitation | ANESTHESIOLOGY, Vol.115(5) : 929-937, 2011 | - |
dc.identifier.rimsid | 27580 | - |
dc.type.rims | ART | - |
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