Cited 3 times in
Amphetamine-induced ERM Proteins Phosphorylation Is through PKCβ Activation in PC12 Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김정훈 | - |
dc.date.accessioned | 2014-12-20T17:18:07Z | - |
dc.date.available | 2014-12-20T17:18:07Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94341 | - |
dc.description.abstract | Amphetamine, a synthetic psychostimulant, is transported by the dopamine transporter (DAT) to the cytosol and increases the exchange of extracellular amphetamine by intracellular dopamine. Recently, we reported that the phosphorylation levels of ezrin-radixin-moesin (ERM) proteins are regulated by psychostimulant drugs in the nucleus accumbens, a brain area important for drug addiction. However, the significance of ERM proteins phosphorylation in response to drugs of abuse has not been fully investigated. In this study, using PC12 cells as an in vitro cell model, we showed that amphetamine increases ERM proteins phosphorylation and protein kinase C (PKC) β inhibitor, but not extracellular signal-regulated kinase (ERK) or phosphatidylinositol 3-kinases (PI3K) inhibitors, abolished this effect. Further, we observed that DAT inhibitor suppressed amphetamine-induced ERM proteins phosphorylation in PC12 cells. These results suggest that PKCβ-induced DAT regulation may be involved in amphetmaine-induced ERM proteins phosphorylation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 245~249 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Amphetamine-induced ERM Proteins Phosphorylation Is through PKCβ Activation in PC12 Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Ha Jin Jeong | - |
dc.contributor.googleauthor | Jeong-Hoon Kim | - |
dc.contributor.googleauthor | Songhee Jeon | - |
dc.identifier.doi | 10.4196/kjpp.2011.15.4.245 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00908 | - |
dc.relation.journalcode | J02104 | - |
dc.identifier.eissn | 2093-3827 | - |
dc.identifier.pmid | 21994482 | - |
dc.subject.keyword | Amphetamine | - |
dc.subject.keyword | Dopamine transporter | - |
dc.subject.keyword | ERMproteins(ezrin, radixin, moesin) | - |
dc.subject.keyword | PC12cells | - |
dc.subject.keyword | PKCβ | - |
dc.contributor.alternativeName | Kim, Jeong Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 15 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 245 | - |
dc.citation.endPage | 249 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, Vol.15(4) : 245-249, 2011 | - |
dc.identifier.rimsid | 27556 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.