Cited 12 times in
Anemia associated with depressive symptoms in mild cognitive impairment with severe white matter hyperintensities
DC Field | Value | Language |
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dc.contributor.author | 손상준 | - |
dc.contributor.author | 오병훈 | - |
dc.date.accessioned | 2014-12-20T17:18:05Z | - |
dc.date.available | 2014-12-20T17:18:05Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0891-9887 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94340 | - |
dc.description.abstract | Depression with mild cognitive impairment (MCI) may be associated with a high risk of dementia. Likewise, anemia and subcortical ischemic changes might be associated with depression in the elderly individuals. We examined the relationship between anemia, subcortical ischemic changes, and depressive symptoms in 388 elderly patients with MCI (74.0% women, mean age = 71.8) who were evaluated at the Clinical Research Center for Dementia of South Korea. Blood samples were drawn from all consenting participants and depressive symptoms were assessed using the 15-item Geriatric Depression Scale (GDS-15). We also evaluated the severity of white matter hyperintensities (WMH) on brain using magnetic resonance imaging (MRI). After a multivariable adjustment, we found no significant differences in GDS-15 score between anemic and nonanemic groups (F = 3.0, P = .085) and among WMH level groups (F = 0.6, P = .574) independently. However, the interaction between anemia and the severity of WMH was significantly associated with depressive symptoms (analysis of covariance, F = 7.8, P < .001). In post hoc tests, a higher depressive symptom score was observed in anemic participants with severe WMH. Anemia with severe subcortical ischemic changes appears to be related to depressive symptoms in patients with MCI. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 161~167 | - |
dc.relation.isPartOf | JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Anemia/complications* | - |
dc.subject.MESH | Anemia/pathology | - |
dc.subject.MESH | Brain/pathology* | - |
dc.subject.MESH | CognitiveDysfunction/complications* | - |
dc.subject.MESH | CognitiveDysfunction/pathology | - |
dc.subject.MESH | Depression/complications* | - |
dc.subject.MESH | Depression/diagnosis | - |
dc.subject.MESH | Depression/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Geriatric Assessment | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Nerve Fibers, Myelinated/pathology* | - |
dc.subject.MESH | Neuropsychological Tests | - |
dc.subject.MESH | Psychiatric Status Rating Scales | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Anemia associated with depressive symptoms in mild cognitive impairment with severe white matter hyperintensities | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Sang Joon Son | - |
dc.contributor.googleauthor | Kang Soo Lee | - |
dc.contributor.googleauthor | Duk L. Na | - |
dc.contributor.googleauthor | Sang Won Seo | - |
dc.contributor.googleauthor | Chi Hun Kim | - |
dc.contributor.googleauthor | Jong Hun Kim | - |
dc.contributor.googleauthor | Byoung Hoon Oh | - |
dc.contributor.googleauthor | Chang Hyung Hong | - |
dc.identifier.doi | 10.1177/0891988711417132 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01972 | - |
dc.contributor.localId | A02368 | - |
dc.relation.journalcode | J01423 | - |
dc.identifier.pmid | 21856970 | - |
dc.identifier.url | http://jgp.sagepub.com/content/24/3/161.long | - |
dc.subject.keyword | mild cognitive impairment | - |
dc.subject.keyword | depression | - |
dc.subject.keyword | anemia | - |
dc.subject.keyword | white matter hyperintensities | - |
dc.subject.keyword | subcortical ischemic vascular disease | - |
dc.contributor.alternativeName | Son, Sang Joon | - |
dc.contributor.alternativeName | Oh, Byong Hoon | - |
dc.contributor.affiliatedAuthor | Son, Sang Joon | - |
dc.contributor.affiliatedAuthor | Oh, Byong Hoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 24 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 161 | - |
dc.citation.endPage | 167 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, Vol.24(3) : 161-167, 2011 | - |
dc.identifier.rimsid | 27555 | - |
dc.type.rims | ART | - |
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