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Clinical outcomes and factors for response prediction after the first course of corticosteroid therapy in patients with active ulcerative colitis

DC FieldValueLanguage
dc.contributor.author김원호-
dc.contributor.author김태일-
dc.contributor.author박재준-
dc.contributor.author윤진영-
dc.contributor.author천재희-
dc.contributor.author홍성필-
dc.date.accessioned2014-12-20T17:16:58Z-
dc.date.available2014-12-20T17:16:58Z-
dc.date.issued2011-
dc.identifier.issn0815-9319-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/94303-
dc.description.abstractBACKGROUND AND AIMS: Both clinical outcomes and factors predictive for poor response after an initial course of corticosteroids have not yet been well established in the treatment of moderate to severe ulcerative colitis (UC). We therefore evaluated the short- and long-term effects of corticosteroids and prognostic factors in UC patients after such therapy. METHODS: We recruited consecutive patients who had moderate to severe UC and were treated with the first course of systemic corticosteroids between November 1996 and December 2007 using the database of Severance Hospital in Seoul, Korea. We then evaluated clinical outcomes at 1 month, 3 months, and 1 year after the initiation of corticosteroid treatment. RESULTS: Our study included a total of 177 patients. At 1 month, complete remission was achieved in 70 patients (39.5%) and partial remission in 88 (49.7%). Fifteen patients (8.5%) were refractory to the treatment, and four (2.3%) underwent proctocolectomy. We observed prolonged response in 111 (64.9%) at 3 months and 95 (59.4%) patients at 1 year, corticosteroid dependency in 49 (28.7%) and 51 (31.9%) patients, and no response in 11 (6.4%) and 14 (8.7%) patients. A higher initial Mayo score was found to be the only poor prognostic factor at 1 month (P = 0.032) and 1 year (P < 0.001). CONCLUSIONS: Our data showed that most Korean patients with active UC responded well to the first course of corticosteroid treatment. However, a considerable number of patients eventually turned out to be refractory to or dependent on this therapy. The initial higher Mayo score was strongly associated with poor outcomes.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1114~1122-
dc.relation.isPartOfJournal of Gastroenterology and Hepatology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleClinical outcomes and factors for response prediction after the first course of corticosteroid therapy in patients with active ulcerative colitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJin Young Yoon-
dc.contributor.googleauthorJae Hee Cheon-
dc.contributor.googleauthorWon Ho Kim-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorSung Pil Hong-
dc.contributor.googleauthorJae Jun Park-
dc.identifier.doi10.1111/j.1440-1746.2011.06688.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ01417-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2011.06688.x/abstract-
dc.contributor.alternativeNameKim, Won Ho-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNamePark, Jae Jun-
dc.contributor.alternativeNameYoon, Jin Young-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.alternativeNameHong, Sung Pil-
dc.identifier.localIdT201103421-
dc.rights.accessRightsnot free-
dc.citation.volume26-
dc.citation.number7-
dc.citation.startPage1114-
dc.citation.endPage1122-
dc.identifier.bibliographicCitationJournal of Gastroenterology and Hepatology, Vol.26(7) : 1114-1122, 2011-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)

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