Cited 19 times in
Clinical outcomes and factors for response prediction after the first course of corticosteroid therapy in patients with active ulcerative colitis
DC Field | Value | Language |
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dc.contributor.author | 김원호 | - |
dc.contributor.author | 김태일 | - |
dc.contributor.author | 박재준 | - |
dc.contributor.author | 윤진영 | - |
dc.contributor.author | 천재희 | - |
dc.contributor.author | 홍성필 | - |
dc.date.accessioned | 2014-12-20T17:16:58Z | - |
dc.date.available | 2014-12-20T17:16:58Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94303 | - |
dc.description.abstract | BACKGROUND AND AIMS: Both clinical outcomes and factors predictive for poor response after an initial course of corticosteroids have not yet been well established in the treatment of moderate to severe ulcerative colitis (UC). We therefore evaluated the short- and long-term effects of corticosteroids and prognostic factors in UC patients after such therapy. METHODS: We recruited consecutive patients who had moderate to severe UC and were treated with the first course of systemic corticosteroids between November 1996 and December 2007 using the database of Severance Hospital in Seoul, Korea. We then evaluated clinical outcomes at 1 month, 3 months, and 1 year after the initiation of corticosteroid treatment. RESULTS: Our study included a total of 177 patients. At 1 month, complete remission was achieved in 70 patients (39.5%) and partial remission in 88 (49.7%). Fifteen patients (8.5%) were refractory to the treatment, and four (2.3%) underwent proctocolectomy. We observed prolonged response in 111 (64.9%) at 3 months and 95 (59.4%) patients at 1 year, corticosteroid dependency in 49 (28.7%) and 51 (31.9%) patients, and no response in 11 (6.4%) and 14 (8.7%) patients. A higher initial Mayo score was found to be the only poor prognostic factor at 1 month (P = 0.032) and 1 year (P < 0.001). CONCLUSIONS: Our data showed that most Korean patients with active UC responded well to the first course of corticosteroid treatment. However, a considerable number of patients eventually turned out to be refractory to or dependent on this therapy. The initial higher Mayo score was strongly associated with poor outcomes. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1114~1122 | - |
dc.relation.isPartOf | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Colitis,Ulcerative/diagnosis | - |
dc.subject.MESH | Colitis,Ulcerative/drugtherapy* | - |
dc.subject.MESH | Colonoscopy | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Dose-ResponseRelationship, Drug | - |
dc.subject.MESH | Drug Administration Routes | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Glucocorticoids/administration & dosage | - |
dc.subject.MESH | Glucocorticoids/therapeutic use* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | TimeFactors | - |
dc.subject.MESH | Young Adult | - |
dc.title | Clinical outcomes and factors for response prediction after the first course of corticosteroid therapy in patients with active ulcerative colitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jin Young Yoon | - |
dc.contributor.googleauthor | Jae Hee Cheon | - |
dc.contributor.googleauthor | Jae Jun Park | - |
dc.contributor.googleauthor | Sung Pil Hong | - |
dc.contributor.googleauthor | Tae Il Kim | - |
dc.contributor.googleauthor | Won Ho Kim | - |
dc.identifier.doi | 10.1111/j.1440-1746.2011.06688.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00774 | - |
dc.contributor.localId | A01079 | - |
dc.contributor.localId | A01636 | - |
dc.contributor.localId | A02612 | - |
dc.contributor.localId | A04404 | - |
dc.contributor.localId | A04030 | - |
dc.relation.journalcode | J01417 | - |
dc.identifier.eissn | 1440-1746 | - |
dc.identifier.pmid | 21299620 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2011.06688.x/abstract | - |
dc.subject.keyword | clinical outcome | - |
dc.subject.keyword | corticosteroid | - |
dc.subject.keyword | Mayo score | - |
dc.subject.keyword | ulcerative colitis | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.alternativeName | Kim, Tae Il | - |
dc.contributor.alternativeName | Park, Jae Jun | - |
dc.contributor.alternativeName | Yoon, Jin Young | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.alternativeName | Hong, Sung Pil | - |
dc.contributor.affiliatedAuthor | Kim, Won Ho | - |
dc.contributor.affiliatedAuthor | Kim, Tae Il | - |
dc.contributor.affiliatedAuthor | Park, Jae Jun | - |
dc.contributor.affiliatedAuthor | Yoon, Jin Young | - |
dc.contributor.affiliatedAuthor | Hong, Sung Pil | - |
dc.contributor.affiliatedAuthor | Cheon, Jae Hee | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 26 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1114 | - |
dc.citation.endPage | 1122 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.26(7) : 1114-1122, 2011 | - |
dc.identifier.rimsid | 27529 | - |
dc.type.rims | ART | - |
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