Cited 13 times in
Coenzyme Q10 protects neurons against neurotoxicity in hippocampal slice culture
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이배환 | - |
dc.date.accessioned | 2014-12-20T17:16:50Z | - |
dc.date.available | 2014-12-20T17:16:50Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94299 | - |
dc.description.abstract | This study investigated the neuroprotective effects of coenzyme Q10 (CoQ10) against oxidative stress induced by kainic acid (KA) in organotypic hippocampal slice culture of rats. Cultured slices were injured by exposure to 5 µM of KA for 18 h and then treated with different concentrations of CoQ10. Neuronal cell death measured as propidium iodide uptake was reduced at 24 h after treatment with 1 µM of CoQ10. We also observed an increased number of surviving CA3 neurons in 0.1 and 1 µM concentrations of CoQ10-treated groups using cresyl violet staining. CoQ10 (0.01, 0.1, and 1 µM) treatment significantly decreased the 2',7'-dichlorofluorescein fluorescence and the expression of NQO1 in the CoQ10-treated groups was significantly lower than that in the KA-only group. These results suggest that CoQ10 may protect hippocampal neurons against oxidative stress | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 721~726 | - |
dc.relation.isPartOf | NEUROREPORT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Death/drug effects | - |
dc.subject.MESH | Cell Death/physiology | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Cell Survival/physiology | - |
dc.subject.MESH | Hippocampus/drug effects | - |
dc.subject.MESH | Hippocampus/physiology | - |
dc.subject.MESH | Kainic Acid/toxicity | - |
dc.subject.MESH | Neurons/drug effects | - |
dc.subject.MESH | Neurons/metabolism* | - |
dc.subject.MESH | Neuroprotective Agents/pharmacology* | - |
dc.subject.MESH | OrganCultureTechniques | - |
dc.subject.MESH | Oxidative Stress/drug effects | - |
dc.subject.MESH | Oxidative Stress/physiology | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Ubiquinone/analogs & derivatives* | - |
dc.subject.MESH | Ubiquinone/physiology | - |
dc.title | Coenzyme Q10 protects neurons against neurotoxicity in hippocampal slice culture | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Ran Won | - |
dc.contributor.googleauthor | Kyung Hee Lee | - |
dc.contributor.googleauthor | Bae Hwan Lee | - |
dc.identifier.doi | 10.1097/WNR.0b013e32834acb8d | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02791 | - |
dc.relation.journalcode | J02361 | - |
dc.identifier.eissn | 1473-558X | - |
dc.identifier.pmid | 21849914 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201110050-00011&LSLINK=80&D=ovft | - |
dc.subject.keyword | antioxidant | - |
dc.subject.keyword | coenzyme Q10 | - |
dc.subject.keyword | kainic acid | - |
dc.subject.keyword | organotypic hippocampal slice culture | - |
dc.subject.keyword | oxidative stress | - |
dc.contributor.alternativeName | Lee, Bae Hwan | - |
dc.contributor.affiliatedAuthor | Lee, Bae Hwan | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 22 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 721 | - |
dc.citation.endPage | 726 | - |
dc.identifier.bibliographicCitation | NEUROREPORT, Vol.22(14) : 721-726, 2011 | - |
dc.identifier.rimsid | 27526 | - |
dc.type.rims | ART | - |
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