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Association of high metabolic activity measured by positron emission tomography imaging with poor prognosis of choroidal melanoma

Authors
 Christopher Seungkyu Lee  ;  Arthur Cho  ;  Sung Chul Lee  ;  Kyu Sung Lee 
Citation
 British Journal of Ophthalmology, Vol.95(11) : 1588-1591, 2011 
Journal Title
 British Journal of Ophthalmology 
ISSN
 0007-1161 
Issue Date
2011
Abstract
AIMS: To evaluate the prognostic value of positron emission tomography (PET) imaging in patients with choroidal melanoma. METHODS: We undertook a retrospective review of 40 consecutive patients with choroidal melanoma who underwent pretreatment whole-body PET, received either brachytherapy using ruthenium-106 plaque, enucleation or gamma knife radiotherapy, and had 1 year of follow-up. Metabolic activity of choroidal melanoma measured as standardised uptake value (SUV) by PET imaging was evaluated with respect to the survival of patients. RESULTS: SUV (p=0.003) and the largest basal diameter of the tumour (p=0.003) were significantly correlated with metastatic death (Cox proportional hazards regression). There was an inverse correlation between tumour metabolic activity and time to metastasis (p=0.049; linear regression). CONCLUSION: Metabolic activity by PET imaging significantly predicted the survival of patients with choroidal melanoma.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94252
DOI
10.1136/bjo.2010.198085
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실)
Yonsei Authors
이규성(Lee, Kyu Sung) ; 이성철(Lee, Sung Chul) ; 이승규(Lee, Seung Kyu) ; 조응혁(Cho, Arthur Eung Hyuck)
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Full Text
http://bjo.bmj.com/content/95/11/1588.long
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