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Deregulated expression of microRNA-221 with the potential for prognostic biomarkers in surgically resected hepatocellular carcinoma

DC Field Value Language
dc.contributor.author윤선옥-
dc.date.accessioned2014-12-20T17:15:08Z-
dc.date.available2014-12-20T17:15:08Z-
dc.date.issued2011-
dc.identifier.issn0046-8177-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/94244-
dc.description.abstractAberrant expression of specific microRNAs in hepatocellular carcinomas has recently been reported. We examined expression patterns of 4 microRNAs (microRNA-221, microRNA-222, microRNA-21, and microRNA-155) to evaluate their potential as relevant biomarkers by quantitative real-time reverse transcriptase-polymerase chain reaction using formalin-fixed, paraffin-embedded tissues of 115 surgically resected hepatocellular carcinoma and paired nonneoplastic liver cases as well as 21 normal liver samples from cancer-free individuals. MicroRNA-221, microRNA-222, and microRNA-21 were differentially overexpressed in hepatocellular carcinoma compared with nonneoplastic and normal livers (P < .001). The mean fold changes in microRNA-221, microRNA-222, and microRNA-21(hepatocellular carcinoma to matched nonneoplastic liver) were 4.00, 4.44, and, 3.67, respectively. In addition, nonneoplastic liver tissues displayed higher levels of microRNA-221, microRNA-222, microRNA-21, and microRNA-155 than normal livers (P < .001, respectively). However, the overexpression of the 4 microRNAs showed no consistent relevance to the known prognostic clinicopathologic parameters. High expression of microRNA-221 in hepatocellular carcinomas was significantly related to shorter time to local recurrence (P < .001) and determined as an independent predictor for local recurrence (P = .001). The fold changes in microRNA-221 (hepatocellular carcinoma to matched nonneoplastic liver) less than 1 were more commonly detected in cases of distant metastases than those of disease-free and local recurrence (P = .009). The fold changes less than 1 were related to reduced metastasis-free survival (P = .006) and thus can be used as an independent predictor of distant metastasis after surgical resection (P = .027). Based on these results, we propose the possible role of microRNA-221, microRNA-222, microRNA-21, and microRNA-155 dysregulation in hepatocarcinogenesis and the potential of microRNA-221 dysregulation for predicting local recurrence and distant metastasis after curative surgery.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1391~1400-
dc.relation.isPartOfHUMAN PATHOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers, Tumor/biosynthesis*-
dc.subject.MESHCarcinoma,Hepatocellular/diagnosis-
dc.subject.MESHCarcinoma,Hepatocellular/metabolism*-
dc.subject.MESHCarcinoma,Hepatocellular/surgery-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLiver/metabolism-
dc.subject.MESHLiver/surgery-
dc.subject.MESHLiver Neoplasms/diagnosis-
dc.subject.MESHLiver Neoplasms/metabolism*-
dc.subject.MESHLiver Neoplasms/surgery-
dc.subject.MESHMale-
dc.subject.MESHMicroRNAs/biosynthesis*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Metastasis-
dc.subject.MESHNeoplasm Recurrence, Local/diagnosis-
dc.subject.MESHNeoplasm Recurrence, Local/metabolism-
dc.subject.MESHPrognosis-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHUp-Regulation-
dc.titleDeregulated expression of microRNA-221 with the potential for prognostic biomarkers in surgically resected hepatocellular carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorSun Och Yoon-
dc.contributor.googleauthorSung-Min Chun-
dc.contributor.googleauthorEun Hee Han-
dc.contributor.googleauthorJene Choi-
dc.contributor.googleauthorSe Jin Jang-
dc.contributor.googleauthorSeung A Koh-
dc.contributor.googleauthorShin Hwang-
dc.contributor.googleauthorEunsil Yu-
dc.identifier.doi10.1016/j.humpath.2010.12.010-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02566-
dc.relation.journalcodeJ01011-
dc.identifier.eissn1532-8392-
dc.identifier.pmid21458843-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0046817711000190-
dc.subject.keywordMicrorna-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordRT-PCR-
dc.subject.keywordFormalin-fixed, paraffin-embedded tissue-
dc.contributor.alternativeNameYoon, Sun Och-
dc.contributor.affiliatedAuthorYoon, Sun Och-
dc.rights.accessRightsnot free-
dc.citation.volume42-
dc.citation.number10-
dc.citation.startPage1391-
dc.citation.endPage1400-
dc.identifier.bibliographicCitationHUMAN PATHOLOGY, Vol.42(10) : 1391-1400, 2011-
dc.identifier.rimsid27488-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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