Cited 59 times in
Deregulated expression of microRNA-221 with the potential for prognostic biomarkers in surgically resected hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | 윤선옥 | - |
dc.date.accessioned | 2014-12-20T17:15:08Z | - |
dc.date.available | 2014-12-20T17:15:08Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0046-8177 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94244 | - |
dc.description.abstract | Aberrant expression of specific microRNAs in hepatocellular carcinomas has recently been reported. We examined expression patterns of 4 microRNAs (microRNA-221, microRNA-222, microRNA-21, and microRNA-155) to evaluate their potential as relevant biomarkers by quantitative real-time reverse transcriptase-polymerase chain reaction using formalin-fixed, paraffin-embedded tissues of 115 surgically resected hepatocellular carcinoma and paired nonneoplastic liver cases as well as 21 normal liver samples from cancer-free individuals. MicroRNA-221, microRNA-222, and microRNA-21 were differentially overexpressed in hepatocellular carcinoma compared with nonneoplastic and normal livers (P < .001). The mean fold changes in microRNA-221, microRNA-222, and microRNA-21(hepatocellular carcinoma to matched nonneoplastic liver) were 4.00, 4.44, and, 3.67, respectively. In addition, nonneoplastic liver tissues displayed higher levels of microRNA-221, microRNA-222, microRNA-21, and microRNA-155 than normal livers (P < .001, respectively). However, the overexpression of the 4 microRNAs showed no consistent relevance to the known prognostic clinicopathologic parameters. High expression of microRNA-221 in hepatocellular carcinomas was significantly related to shorter time to local recurrence (P < .001) and determined as an independent predictor for local recurrence (P = .001). The fold changes in microRNA-221 (hepatocellular carcinoma to matched nonneoplastic liver) less than 1 were more commonly detected in cases of distant metastases than those of disease-free and local recurrence (P = .009). The fold changes less than 1 were related to reduced metastasis-free survival (P = .006) and thus can be used as an independent predictor of distant metastasis after surgical resection (P = .027). Based on these results, we propose the possible role of microRNA-221, microRNA-222, microRNA-21, and microRNA-155 dysregulation in hepatocarcinogenesis and the potential of microRNA-221 dysregulation for predicting local recurrence and distant metastasis after curative surgery. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1391~1400 | - |
dc.relation.isPartOf | HUMAN PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers, Tumor/biosynthesis* | - |
dc.subject.MESH | Carcinoma,Hepatocellular/diagnosis | - |
dc.subject.MESH | Carcinoma,Hepatocellular/metabolism* | - |
dc.subject.MESH | Carcinoma,Hepatocellular/surgery | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver/metabolism | - |
dc.subject.MESH | Liver/surgery | - |
dc.subject.MESH | Liver Neoplasms/diagnosis | - |
dc.subject.MESH | Liver Neoplasms/metabolism* | - |
dc.subject.MESH | Liver Neoplasms/surgery | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | MicroRNAs/biosynthesis* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Neoplasm Recurrence, Local/diagnosis | - |
dc.subject.MESH | Neoplasm Recurrence, Local/metabolism | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Up-Regulation | - |
dc.title | Deregulated expression of microRNA-221 with the potential for prognostic biomarkers in surgically resected hepatocellular carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Sun Och Yoon | - |
dc.contributor.googleauthor | Sung-Min Chun | - |
dc.contributor.googleauthor | Eun Hee Han | - |
dc.contributor.googleauthor | Jene Choi | - |
dc.contributor.googleauthor | Se Jin Jang | - |
dc.contributor.googleauthor | Seung A Koh | - |
dc.contributor.googleauthor | Shin Hwang | - |
dc.contributor.googleauthor | Eunsil Yu | - |
dc.identifier.doi | 10.1016/j.humpath.2010.12.010 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02566 | - |
dc.relation.journalcode | J01011 | - |
dc.identifier.eissn | 1532-8392 | - |
dc.identifier.pmid | 21458843 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0046817711000190 | - |
dc.subject.keyword | Microrna | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | RT-PCR | - |
dc.subject.keyword | Formalin-fixed, paraffin-embedded tissue | - |
dc.contributor.alternativeName | Yoon, Sun Och | - |
dc.contributor.affiliatedAuthor | Yoon, Sun Och | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 42 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1391 | - |
dc.citation.endPage | 1400 | - |
dc.identifier.bibliographicCitation | HUMAN PATHOLOGY, Vol.42(10) : 1391-1400, 2011 | - |
dc.identifier.rimsid | 27488 | - |
dc.type.rims | ART | - |
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