1 546

Cited 17 times in

Healing effects of rebamipide and omeprazole in Helicobacter pylori-positive gastric ulcer patients after eradication therapy: a randomized double-blind, multinational, multi-institutional comparative study

DC Field Value Language
dc.contributor.author이용찬-
dc.date.accessioned2014-12-20T17:13:17Z-
dc.date.available2014-12-20T17:13:17Z-
dc.date.issued2011-
dc.identifier.issn0012-2823-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/94186-
dc.description.abstractBACKGROUND AND AIMS: A recent placebo-controlled trial showed that rebamipide, which is a mucosal-protective antiulcer agent, promoted gastric ulcer healing without affecting the Helicobacter pylori status. We conducted a randomized, double-blind trial to compare the healing effects of rebamipide and the proton-pump inhibitor omeprazole in H. pylori-positive gastric ulcers after H. pylori eradication therapy. METHODS: After completion of 1 week of eradication therapy, 132 patients with H. pylori-positive gastric ulcer were enrolled in 5 Chinese and 4 Korean institutions. Patients were randomly assigned to take either 20 mg of omeprazole (n = 63) or 300 mg of rebamipide (n = 65) daily for 7 weeks. Healing was defined as complete recovery and S1 and S2 stage ulcer according to the Sakita-Miwa classification. RESULTS: Healing rates at 12 weeks were 81.5% (53/65) and 82.5% (52/63) in the rebamipide and omeprazole groups, respectively. There was no significant difference in treatment efficacy, as evidenced by gastric ulcer healing rates (absolute difference -1.0%; 95% confidence interval -10.7 to 8.7; p = 0.88). The H. pylori eradication rate and ulcer healing rate did not differ between the groups, the latter regardless of eradication outcome. CONCLUSIONS: Rebamipide is as effective as omeprazole in treating of H. pylori-positive gastric ulcer after eradication therapy.-
dc.description.statementOfResponsibilityopen-
dc.format.extent221~229-
dc.relation.isPartOfDIGESTION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAlanine/adverseeffects-
dc.subject.MESHAlanine/analogs & derivatives*-
dc.subject.MESHAlanine/therapeutic use-
dc.subject.MESHAmoxicillin/therapeutic use-
dc.subject.MESHAnti-Bacterial Agents/therapeutic use-
dc.subject.MESHAnti-UlcerAgents/therapeutic use*-
dc.subject.MESHClarithromycin/therapeutic use-
dc.subject.MESHDouble-BlindMethod-
dc.subject.MESHFemale-
dc.subject.MESHHelicobacterInfections/drugtherapy-
dc.subject.MESHHelicobacterInfections/microbiology*-
dc.subject.MESHHelicobacterpylori*-
dc.subject.MESHHumans-
dc.subject.MESHIntention to Treat Analysis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOmeprazole/adverseeffects-
dc.subject.MESHOmeprazole/therapeutic use*-
dc.subject.MESHQuinolones/adverseeffects-
dc.subject.MESHQuinolones/therapeutic use*-
dc.subject.MESHStomachUlcer/drugtherapy*-
dc.subject.MESHStomachUlcer/microbiology-
dc.subject.MESHStomachUlcer/pathology-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHWoundHealing-
dc.subject.MESHYoung Adult-
dc.titleHealing effects of rebamipide and omeprazole in Helicobacter pylori-positive gastric ulcer patients after eradication therapy: a randomized double-blind, multinational, multi-institutional comparative study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSong K.H.-
dc.contributor.googleauthorLee Y.C.-
dc.contributor.googleauthorFan D.-M.-
dc.contributor.googleauthorGe Z.-Z.-
dc.contributor.googleauthorJi F.-
dc.contributor.googleauthorChen M.-H.-
dc.contributor.googleauthorJung H.C.-
dc.contributor.googleauthorBo J.-
dc.contributor.googleauthorLee S.W.-
dc.contributor.googleauthorKim J.-H.-
dc.identifier.doi10.1159/000329353-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02988-
dc.relation.journalcodeJ00734-
dc.identifier.eissn1421-9867-
dc.identifier.pmid21757914-
dc.identifier.urlhttp://www.karger.com/Article/FullText/329353-
dc.subject.keywordGastric ulcer-
dc.subject.keywordHelicobacter pylori-
dc.subject.keywordOmeprazole-
dc.subject.keywordProton pump inhibitor-
dc.subject.keywordRebamipide-
dc.subject.keywordTreatment efficacy-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.rights.accessRightsnot free-
dc.citation.volume84-
dc.citation.number3-
dc.citation.startPage221-
dc.citation.endPage229-
dc.identifier.bibliographicCitationDIGESTION, Vol.84(3) : 221-229, 2011-
dc.identifier.rimsid27297-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.