Cited 19 times in
Predictive characteristics of patients achieving glycaemic control with insulin after sulfonylurea failure
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이병완 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2014-12-20T17:10:04Z | - |
dc.date.available | 2014-12-20T17:10:04Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1368-5031 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94085 | - |
dc.description.abstract | AIM: We investigated the clinical and metabolic parameters in type 2 diabetic patients who were inadequately controlled on sulfonylurea (SU) before initiating insulin therapy to characterise patients who are likely to achieve target glycaemic control with insulin analogues. METHODS: A total of 120 Korean patients aged ≥ 40 years with insulin-naïve, poorly controlled, SU-treated type 2 diabetes were randomised on the basis of SU dose, and obesity with 1 : 1 ratio of insulin detemir (long-acting analogue; LAA) and 70% insulin aspart protamine and 30% insulin aspart (biphasic insulin analogue; BIA). Patients who failed to reach ≤ 20% glycated albumin (GA) at 3 weeks were switched to therapy with a twice-daily BIA for 16 weeks. RESULTS: Mean HbA(1c) , GA, fasting and stimulated plasma glucose levels were significantly reduced after 16 weeks compared with the baseline in all groups, and 40% of patients reached the target HbA(1c) ( ≤ 7%). Compared with responders, non-responders had significantly longer duration of diabetes and higher dose of glimepiride. However, there was no significant difference in insulin secretory profiles between responders and non-responders. Clinical factors such as diabetes duration, SU dose and BMI were independently associated with inadequate response to insulin analogues in patients with secondary failure. CONCLUSIONS: In type 2 diabetics with secondary SU failure, clinical parameters such as duration of diabetes (< 10 years), SU dose ( ≤ 4 mg) and BMI should be taken into consideration as important factors than laboratory indices related to β-cell function when predicting the response to insulin analogues. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1076~1084 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CLINICAL PRACTICE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Administration, Oral | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Blood Glucose/metabolism* | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/complications | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/drug therapy* | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/physiopathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glycated Hemoglobin A/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypoglycemic Agents/therapeutic use* | - |
dc.subject.MESH | Insulin/analogs & derivatives* | - |
dc.subject.MESH | Insulin-Secreting Cells/physiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Obesity/complications | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | SulfonylureaCompounds/therapeutic use* | - |
dc.subject.MESH | TreatmentFailure | - |
dc.title | Predictive characteristics of patients achieving glycaemic control with insulin after sulfonylurea failure | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Y.-H. Lee | - |
dc.contributor.googleauthor | B.-W. Lee | - |
dc.contributor.googleauthor | S. W. Chun | - |
dc.contributor.googleauthor | B. S. Cha | - |
dc.contributor.googleauthor | H. C. Lee | - |
dc.identifier.doi | 10.1111/j.1742-1241.2011.02755.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02796 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A02989 | - |
dc.relation.journalcode | J01099 | - |
dc.identifier.eissn | 1742-1241 | - |
dc.identifier.pmid | 21923847 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1742-1241.2011.02755.x/abstract | - |
dc.contributor.alternativeName | Lee, Byung Wan | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Lee, Byung Wan | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Lee, Yong Ho | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 65 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1076 | - |
dc.citation.endPage | 1084 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Vol.65(10) : 1076-1084, 2011 | - |
dc.identifier.rimsid | 27227 | - |
dc.type.rims | ART | - |
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