Cited 51 times in
Regulation of sodium transport in the inner ear
DC Field | Value | Language |
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dc.contributor.author | 김성헌 | - |
dc.date.accessioned | 2014-12-20T17:09:43Z | - |
dc.date.available | 2014-12-20T17:09:43Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0378-5955 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94074 | - |
dc.description.abstract | Na(+) concentrations in endolymph must be controlled to maintain hair cell function since the transduction channels of hair cells are cation-permeable, but not K(+)-selective. Flooding or fluctuations of the hair cell cytosol with Na(+) would be expected to lead to cellular dysfunction, hearing loss and vertigo. This review briefly describes cellular mechanisms known to be responsible for Na(+) homeostasis in each compartment of the inner ear, including the cochlea, saccule, semicircular canals and endolymphatic sac. The influx of Na(+) into endolymph of each of the organs is likely via passive diffusion, but these pathways have not yet been identified or characterized. Na(+) absorption is controlled by gate-keeper channels in the apical (endolymphatic) membrane of the transporting cells. Highly Na(+)-selective epithelial sodium channels (ENaCs) control absorption by Reissner's membrane, saccular extramacular epithelium, semicircular canal duct epithelium and endolymphatic sac. ENaC activity is controlled by a number of signal pathways, but most notably by genomic regulation of channel numbers in the membrane via glucocorticoid signaling. Non-selective cation channels in the apical membrane of outer sulcus epithelial cells and vestibular transitional cells mediate Na(+) and parasensory K(+) absorption. The K(+)-mediated transduction current in hair cells is also accompanied by a Na(+) flux since the transduction channels are non-selective cation channels. Cation absorption by all of these cells is regulated by extracellular ATP via apical non-selective cation channels (P2X receptors). The heterogeneous population of epithelial cells in the endolymphatic sac is thought to have multiple absorptive pathways for Na(+) with regulatory pathways that include glucocorticoids and purinergic agonists. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 21~29 | - |
dc.relation.isPartOf | HEARING RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cochlea/physiology | - |
dc.subject.MESH | Ear, Inner/physiology* | - |
dc.subject.MESH | Endolymphatic Sac/physiology | - |
dc.subject.MESH | Homeostasis/physiology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ion Transport/physiology | - |
dc.subject.MESH | Saccule and Utricle/physiology | - |
dc.subject.MESH | Semicircular Canals/physiology | - |
dc.subject.MESH | Sodium/metabolism* | - |
dc.title | Regulation of sodium transport in the inner ear | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학) | - |
dc.contributor.googleauthor | Sung Huhn Kim | - |
dc.contributor.googleauthor | Daniel C. Marcus | - |
dc.identifier.doi | 10.1016/j.heares.2011.05.003 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00589 | - |
dc.relation.journalcode | J00975 | - |
dc.identifier.eissn | 1878-5891 | - |
dc.identifier.pmid | 21620939 | - |
dc.subject.keyword | inner ear | - |
dc.subject.keyword | sodium homeostasis | - |
dc.subject.keyword | epithelial sodium channel | - |
dc.subject.keyword | Meniere’s disease | - |
dc.contributor.alternativeName | Kim, Sung Huhn | - |
dc.contributor.affiliatedAuthor | Kim, Sung Huhn | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 280 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 21 | - |
dc.citation.endPage | 29 | - |
dc.identifier.bibliographicCitation | HEARING RESEARCH, Vol.280(1-2) : 21-29, 2011 | - |
dc.identifier.rimsid | 27217 | - |
dc.type.rims | ART | - |
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