Cited 9 times in
The effect of anemia and left ventricular geometric patterns on renal disease progression in type 2 diabetic nephropathy.
DC Field | Value | Language |
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dc.contributor.author | 김좌경 | - |
dc.contributor.author | 문성진 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 박형천 | - |
dc.contributor.author | 배기선 | - |
dc.contributor.author | 이정은 | - |
dc.contributor.author | 임세중 | - |
dc.contributor.author | 하성규 | - |
dc.date.accessioned | 2014-12-20T17:07:55Z | - |
dc.date.available | 2014-12-20T17:07:55Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1121-8428 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94021 | - |
dc.description.abstract | BACKGROUND: Left ventricular (LV) geometric patterns have never been evaluated as independent risk factors for renal disease progression (RDP). We investigated the risk factors for RDP in type 2 diabetic nephropathy patients, especially focusing on the effects of LV geometric patterns. METHODS: This was a single-center retrospective cohort study. Type 2 diabetic nephropathy patients who underwent echocardiography for routine checkup were recruited. Baseline laboratory data within 1 month from the time of echocardiography and clinical and follow-up laboratory data were collected by retrospective reviews. RESULTS: A total of 150 patients (90 men, mean age 62.9 years) were enrolled. Distributions of the patients according to LV geometric patterns were as follows: normal 21 (14.0%), concentric remodeling 18 (12.0%), concentric hypertrophy 70 (46.7%) and eccentric hypertrophy 41 (27.3%). During the study period (30.1 ± 19.4 months), RDP developed in 53 of 150 patients (35.3%). On univariate analysis, use of erythropoiesis-stimulating agent, hemoglobin, serum creatinine, estimated glomerular filtration rate (eGFR), serum albumin, log-transformed 24-hour urine protein, LV mass index and eccentric hypertrophy were strong predictors of renal outcomes. RDP-free survival was significantly decreased in the eccentric hypertrophy group (p=0.001, vs. other groups) according to Kaplan-Meier analysis. On multivariate analysis, eGFR, eccentric hypertrophy and hemoglobin levels were significant predictors of renal outcome. CONCLUSION: Anemia and eccentric hypertrophy may be considered as important risk factors for RDP. Multicenter prospective trials should be needed to validate the effect of LV geometric patterns on RDP. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 50~59 | - |
dc.relation.isPartOf | JOURNAL OF NEPHROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anemia/blood | - |
dc.subject.MESH | Anemia/complications* | - |
dc.subject.MESH | Anemia/drug therapy | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/complications* | - |
dc.subject.MESH | Diabetic Nephropathies/blood | - |
dc.subject.MESH | Diabetic Nephropathies/etiology* | - |
dc.subject.MESH | Diabetic Nephropathies/physiopathology | - |
dc.subject.MESH | Diabetic Nephropathies/therapy | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerular Filtration Rate | - |
dc.subject.MESH | Heart Ventricles/diagnostic imaging | - |
dc.subject.MESH | Heart Ventricles/physiopathology | - |
dc.subject.MESH | Hematinics/therapeutic use | - |
dc.subject.MESH | Hemoglobins/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertrophy, Left Ventricular/complications* | - |
dc.subject.MESH | Hypertrophy, Left Ventricular/diagnostic imaging | - |
dc.subject.MESH | Hypertrophy, Left Ventricular/physiopathology | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Kidney Failure, Chronic/blood | - |
dc.subject.MESH | Kidney Failure, Chronic/etiology* | - |
dc.subject.MESH | Kidney Failure, Chronic/physiopathology | - |
dc.subject.MESH | Kidney Failure, Chronic/therapy | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Renal Replacement Therapy | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Ultrasonography | - |
dc.subject.MESH | Ventricular Remodeling | - |
dc.title | The effect of anemia and left ventricular geometric patterns on renal disease progression in type 2 diabetic nephropathy. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Sung Jin Moon | - |
dc.contributor.googleauthor | Ki Sun Bae | - |
dc.contributor.googleauthor | Hyeong Cheon Park | - |
dc.contributor.googleauthor | Jwa Kyung Kim | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.contributor.googleauthor | Jung Eun Lee | - |
dc.contributor.googleauthor | Se Joong Rim, | - |
dc.contributor.googleauthor | Sung Kyu Ha | - |
dc.identifier.doi | 10.5301/JN.2010.353 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00931 | - |
dc.contributor.localId | A01364 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A01759 | - |
dc.contributor.localId | A01791 | - |
dc.contributor.localId | A03372 | - |
dc.contributor.localId | A04252 | - |
dc.contributor.localId | A03119 | - |
dc.relation.journalcode | J01616 | - |
dc.identifier.eissn | 1724-6059 | - |
dc.identifier.pmid | 20437400 | - |
dc.identifier.url | http://www.jnephrol.com/article/the-effect-of-anemia-and-left-ventricular-geometric-patterns-on-renal-disease-progression-in-type-2-diabetic-nephropathy-jnephrol-09-00159 | - |
dc.subject.keyword | Anemia | - |
dc.subject.keyword | Diabetic nephropathy | - |
dc.subject.keyword | Left ventricular hypertrophy | - |
dc.subject.keyword | Renal disease progression | - |
dc.contributor.alternativeName | Kim, Jwa Kyung | - |
dc.contributor.alternativeName | Moon, Sung Jin | - |
dc.contributor.alternativeName | Park, Jung Tak | - |
dc.contributor.alternativeName | Park, Hyeong Cheon | - |
dc.contributor.alternativeName | Bae, Ki Sun | - |
dc.contributor.alternativeName | Lee, Jung Eun | - |
dc.contributor.alternativeName | Rim, Se Joong | - |
dc.contributor.alternativeName | Ha, Sung Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Jwa Kyung | - |
dc.contributor.affiliatedAuthor | Moon, Sung Jin | - |
dc.contributor.affiliatedAuthor | Park, Jung Tak | - |
dc.contributor.affiliatedAuthor | Park, Hyeong Cheon | - |
dc.contributor.affiliatedAuthor | Bae, Ki Sun | - |
dc.contributor.affiliatedAuthor | Rim, Se Joong | - |
dc.contributor.affiliatedAuthor | Ha, Sung Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Jung Eun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 24 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 50 | - |
dc.citation.endPage | 59 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEPHROLOGY, Vol.24(1) : 50-59, 2011 | - |
dc.identifier.rimsid | 27179 | - |
dc.type.rims | ART | - |
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