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The characteristics of metallo-β-lactamase-producing gram-negative bacilli isolated from sputum and urine: a single center experience in Korea.

DC Field Value Language
dc.contributor.author최석훈-
dc.contributor.author최준용-
dc.contributor.author최희경-
dc.contributor.author한상훈-
dc.contributor.author김준명-
dc.contributor.author김창기-
dc.contributor.author송영구-
dc.contributor.author용동은-
dc.contributor.author이경원-
dc.contributor.author이한성-
dc.contributor.author정수진-
dc.contributor.author진범식-
dc.date.accessioned2014-12-20T17:03:18Z-
dc.date.available2014-12-20T17:03:18Z-
dc.date.issued2011-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93875-
dc.description.abstractMetallo-β-lactamase (MBL) production usually results in high-level resistance to most β-lactams, and a rapid spread of MBL producing major gram-negative pathogens is a matter of particular concern worldwide. However, clinical data are scarce and most studies compared MBL producer (MP) with MBL non-producer (MNP) strains which included carbapenem susceptible isolates. Therefore, we collected clinical data of patients in whom imipenem-nonsusceptible Pseudomonas aeruginosa (PA) and Acinetobacter baumannii (AB) were isolated from sputum or urine, and investigated MBL production and the risk factors related with MBL acquisition. The antimicrobial susceptibility patterns were also compared between MPs and imipenem-nonsusceptible MNPs (INMNP). Among the 176 imipenem-nonsusceptible isolates, 12 MPs (6.8%) were identified. There was no identifiable risk factor that contributed to the acquisition of MPs when compared to INMNPs, and case-fatalities were not different between the two groups. The percentage of susceptible isolates was higher among MPs for piperacilin/tazobactam and fluoroquinolones while that of ceftazidime was higher in INMNPs (p < 0.05). As regards to aztreonam, which has been known to be a uniquely stable β-lactam against MBLs, susceptibility was preserved in only two isolates (16.7%) among MPs, and was not higher than that of INMNPs (23.2%). In conclusion, the contribution of MBLs to imipenem non-susceptibility in PA/ABs isolated from sputum and urine was relatively limited, and there was no significant risk factor associated with acquisition of MPs compared with INMNPs. However, limited susceptibility to aztreonam implies that MPs may hold additional resistance mechanisms, such as extended spectrum β-lactamases, AmpC β-lactamases, or other non-enzymatic mechanisms-
dc.description.statementOfResponsibilityopen-
dc.format.extent351~357-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAnti-Bacterial Agents/pharmacology-
dc.subject.MESHAnti-Bacterial Agents/therapeutic use-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHElectrophoresis, Gel, Pulsed-Field-
dc.subject.MESHFemale-
dc.subject.MESHGram-Negative Bacteria/drug effects-
dc.subject.MESHGram-Negative Bacteria/enzymology*-
dc.subject.MESHGram-Negative Bacteria/isolation & purification-
dc.subject.MESHGram-Negative Bacterial Infections/drug therapy-
dc.subject.MESHGram-Negative Bacterial Infections/enzymology-
dc.subject.MESHGram-Negative Bacterial Infections/microbiology-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMicrobial Sensitivity Tests-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSputum/microbiology*-
dc.subject.MESHUrine/microbiology*-
dc.subject.MESHbeta-Lactam Resistance-
dc.subject.MESHbeta-Lactamases/metabolism*-
dc.titleThe characteristics of metallo-β-lactamase-producing gram-negative bacilli isolated from sputum and urine: a single center experience in Korea.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorBum Sik Chin-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorSuk Hoon Choi-
dc.contributor.googleauthorHan Sung Lee-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorHee Kyung Choi-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorChang Ki Kim-
dc.contributor.googleauthorDongeun Yong-
dc.contributor.googleauthorKyungwon Lee-
dc.contributor.googleauthorJune Myung Kim-
dc.identifier.doi10.3349/ymj.2011.52.2.351-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04071-
dc.contributor.localIdA04191-
dc.contributor.localIdA04228-
dc.contributor.localIdA04286-
dc.contributor.localIdA00953-
dc.contributor.localIdA01038-
dc.contributor.localIdA02037-
dc.contributor.localIdA02423-
dc.contributor.localIdA02649-
dc.contributor.localIdA03277-
dc.contributor.localIdA03638-
dc.contributor.localIdA03981-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid21319358-
dc.contributor.alternativeNameChoi, Suk Hoon-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.alternativeNameChoi, Hee Kyoung-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameKim, Chang Ki-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.alternativeNameYong, Dong Eun-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.alternativeNameLee, Han Sung-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameChin, Bum Sik-
dc.contributor.affiliatedAuthorChoi, Suk Hoon-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.contributor.affiliatedAuthorChoi, Hee Kyoung-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorKim, Chang Ki-
dc.contributor.affiliatedAuthorSong, Young Goo-
dc.contributor.affiliatedAuthorYong, Dong Eun-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorLee, Han Sung-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorChin, Bum Sik-
dc.rights.accessRightsfree-
dc.citation.volume52-
dc.citation.number2-
dc.citation.startPage351-
dc.citation.endPage357-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.52(2) : 351-357, 2011-
dc.identifier.rimsid28518-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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