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Prognostic impact of the lymph node ratio in rectal cancer patients who underwent preoperative chemoradiation

Authors
 Jeonghyun Kang  ;  Hyuk Hur  ;  Byung Soh Min  ;  Kang Young Lee  ;  Nam Kyu Kim 
Citation
 Journal of Surgical Oncology, Vol.104(1) : 53-58, 2011 
Journal Title
 Journal of Surgical Oncology 
ISSN
 0022-4790 
Issue Date
2011
Abstract
AIM: The purpose of this study was to investigate the prognostic impact of the lymph node ratio (LNR) in ypN-positive rectal cancer patients who received preoperative chemoradiation (preop-CRT). METHODS: A total of 75 patients diagnosed as node-positive after undergoing preop-CRT followed by curative resection were enrolled. Patients were categorized into two groups based on their median LNR, 0.143. RESULTS: The median metastatic and retrieved lymph node numbers were 2.0 (range: 1-79) and 18.0 (range: 5-80). Abdominoperineal resection, circumferential resection margin involvement and higher LNR were proven to be independent adverse prognostic factors affecting survival in the multivariate analysis including LNR as a covariate. Of the 47 patients with ypN1, 35 (74.5%) showed a lower LNR (N1G1) and 12 (25.5%) showed a higher LNR (N1G2). The N1G1 group showed better overall survival than the N1G2 group (P = 0.018). There was no difference between the survival rates of the N1G2 group and the ypN2 group (P = 0.987). CONCLUSIONS: LNR is an independent prognostic factor after preop-CRT for rectal cancer. LNR showed better prognosis stratification than the ypN stage. Therefore, LNR should be considered as an additional prognostic factor in node-positive rectal cancer after preop-CRT.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93864
DOI
10.1002/jso.21913
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
강정현(Kang, Jeonghyun) ; 김남규(Kim, Nam Kyu) ; 민병소(Min, Byung Soh) ; 이강영(Lee, Kang Young) ; 허혁(Hur, Hyuk)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jso.21913/abstract
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