Cited 27 times in
Evaluation of neointimal morphology of lesions with or without in-stent restenosis: an optical coherence tomography study.
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 홍명기 | - |
dc.contributor.author | 고영국 | - |
dc.contributor.author | 김병극 | - |
dc.contributor.author | 김중선 | - |
dc.contributor.author | 이성주 | - |
dc.date.accessioned | 2014-12-20T17:01:21Z | - |
dc.date.available | 2014-12-20T17:01:21Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0160-9289 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93814 | - |
dc.description.abstract | BACKGROUND: Characterization of neointimal tissue is essential to understand the pathophysiology of in-stent restenosis (ISR) after drug-eluting stent (DES) implantation. Using optical coherence tomography (OCT), we compared the morphologic characteristics of in-stent neointimal tissue from 33 ISR lesions with those of 192 non-ISR lesions after DES implantation. HYPOTHESIS: We hypothesized that the morphologic characteristics of in-stent neointimal tissue from ISR lesions were different from those of non-ISR lesions after DES implantation. METHODS: The DES were coated with sirolimus (n=52), paclitaxel (n=57), zotarolimus (n=84), or everolimus (n=32). In-stent restenosis was defined as ≥50% diameter stenosis at the follow-up angiogram. Lesions with ≥10% neointimal burden ([neointima area × 100]/[stent area]), as determined by OCT, were included in this study. A follow-up OCT (mean follow-up duration, 12.0 ± 10.5 mo) was performed in 209 patients with 225 lesions (ISR lesions, n=33; non-ISR lesions, n=192). Qualitative OCT was used to assess tissue structure, backscatter, visible microvessels, and presence of intraluminal material. RESULTS: The following characteristics were more common in ISR lesions than in non-ISR lesions: heterogeneous or layered tissues (78.8% vs 22.9%, P<0.001), low backscatter (60.6% vs 20.8%, P<0.001), and microvessels (48.5% vs 5.7%, P<0.001). The independent predictors for heterogeneous or layered neointimal tissues were increased neointima burden (odds ratio [OR]: 1.218, 95% confidence interval [CI]: 1.096-1.354, P<0.001), lumen area (OR: 4.672, 95% CI: 1.371-15.914, P = 0.014), and hypertension (OR: 0.415, 95% CI: 0.186-0.926, P = 0.032). CONCLUSIONS: This follow-up OCT study demonstrated that morphologic characteristics of neointimal tissues of ISR lesions differ from those of non-ISR lesions. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 633~639 | - |
dc.relation.isPartOf | CLINICAL CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Angioplasty, Balloon, Coronary/adverse effects | - |
dc.subject.MESH | Angioplasty, Balloon, Coronary/instrumentation* | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Coronary Angiography | - |
dc.subject.MESH | Coronary Restenosis/diagnosis* | - |
dc.subject.MESH | Coronary Restenosis/etiology | - |
dc.subject.MESH | Coronary Restenosis/pathology | - |
dc.subject.MESH | Coronary Vessels/pathology* | - |
dc.subject.MESH | Drug-Eluting Stents* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prosthesis Design | - |
dc.subject.MESH | Registries | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Tomography, Optical Coherence* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Tunica Intima/pathology* | - |
dc.title | Evaluation of neointimal morphology of lesions with or without in-stent restenosis: an optical coherence tomography study. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Sung-Joo Lee | - |
dc.contributor.googleauthor | Byeong-Keuk Kim | - |
dc.contributor.googleauthor | Jung-Sun Kim | - |
dc.contributor.googleauthor | Young-Guk Ko | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Myeong-Ki Hong | - |
dc.identifier.doi | 10.1002/clc.20960 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A04391 | - |
dc.contributor.localId | A00127 | - |
dc.contributor.localId | A00493 | - |
dc.contributor.localId | A00961 | - |
dc.contributor.localId | A02869 | - |
dc.relation.journalcode | J00565 | - |
dc.identifier.eissn | 1932-8737 | - |
dc.identifier.pmid | 21928365 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/clc.20960/abstract | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Hong, Myeong Ki | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.alternativeName | Kim, Byeong Keuk | - |
dc.contributor.alternativeName | Kim, Jung Sun | - |
dc.contributor.alternativeName | Lee, Sung Joo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Hong, Myeong Ki | - |
dc.contributor.affiliatedAuthor | Ko, Young Guk | - |
dc.contributor.affiliatedAuthor | Kim, Byeong Keuk | - |
dc.contributor.affiliatedAuthor | Kim, Jung Sun | - |
dc.contributor.affiliatedAuthor | Lee, Sung Joo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 34 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 633 | - |
dc.citation.endPage | 639 | - |
dc.identifier.bibliographicCitation | CLINICAL CARDIOLOGY, Vol.34(10) : 633-639, 2011 | - |
dc.identifier.rimsid | 28482 | - |
dc.type.rims | ART | - |
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