Cited 12 times in
Predictive factors for ciclosporin-associated nephrotoxicity in children with minimal change nephrotic syndrome
DC Field | Value | Language |
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dc.contributor.author | 신재일 | - |
dc.contributor.author | 이재승 | - |
dc.contributor.author | 임범진 | - |
dc.contributor.author | 정현주 | - |
dc.contributor.author | 김병길 | - |
dc.contributor.author | 김지홍 | - |
dc.contributor.author | 박세진 | - |
dc.date.accessioned | 2014-12-20T17:00:18Z | - |
dc.date.available | 2014-12-20T17:00:18Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0021-9746 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93789 | - |
dc.description.abstract | AIMS: To identify the predictive factors for ciclosporin A (CyA)-associated nephrotoxicity (CAN) in children with minimal change nephrotic syndrome (MCNS). METHODS: The clinical and laboratory findings of 58 children (median age 3.2 years, range 1.1-13.1 years, male:female 48:10) with MCNS who were treated with CyA from 1992 to 2002 were analysed retrospectively. Forty-eight (83%) of them were steroid dependent and 10 (17%) were steroid resistant. The starting dose of CyA was 5mg/kg per day, and the desired drug level was kept at 100-200 ng/ml. Serial renal biopsies were performed before and after CyA therapy. RESULTS: Twenty-two patients (38%) had CAN (group I) and 36 (62%) did not (group II). There were no differences in the age at onset, sex, initial response to steroids, duration of CyA therapy and relapse rates. However, the median CyA trough levels were significantly higher in group I than in group II (218.0±15.2 vs 171.8±6.7 ng/ml, p=0.01). Changes in creatinine clearance were more decreased in group I than in group II (-39.4±8.2 vs 2.7±4.3 ml/min per 1.73m(2), p<0.0001). Multiple logistic regression analysis also revealed the median CyA trough level was an independent risk factor for the development of CAN (OR 1.025, 95% CI 1.007 to 1.044, p=0.007). CONCLUSIONS: The median CyA trough level was an independent and significant risk factor for the development of CAN in children with MCNS receiving moderate-dose CyA. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 516~519 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Cyclosporine/adverse effects* | - |
dc.subject.MESH | Cyclosporine/blood | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppressive Agents/adverse effects* | - |
dc.subject.MESH | Immunosuppressive Agents/blood | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Kidney Diseases/blood | - |
dc.subject.MESH | Kidney Diseases/chemically induced* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Nephrosis, Lipoid/drug therapy* | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Predictive factors for ciclosporin-associated nephrotoxicity in children with minimal change nephrotic syndrome | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Ji Hong Kim | - |
dc.contributor.googleauthor | Se Jin Park | - |
dc.contributor.googleauthor | So Jin Yoon | - |
dc.contributor.googleauthor | Beom Jin Lim | - |
dc.contributor.googleauthor | Hyeon Joo Jeong | - |
dc.contributor.googleauthor | Jae Seung Lee | - |
dc.contributor.googleauthor | Pyung Kil Kim | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.identifier.doi | 10.1136/jclinpath-2011-200005 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01003 | - |
dc.contributor.localId | A02142 | - |
dc.contributor.localId | A03076 | - |
dc.contributor.localId | A03363 | - |
dc.contributor.localId | A03771 | - |
dc.contributor.localId | A00494 | - |
dc.contributor.localId | A01523 | - |
dc.relation.journalcode | J01334 | - |
dc.identifier.eissn | 1472-4146 | - |
dc.identifier.pmid | 21441261 | - |
dc.identifier.url | http://jcp.bmj.com/content/64/6/516 | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.alternativeName | Lee, Jae Seung | - |
dc.contributor.alternativeName | Lim, Beom Jin | - |
dc.contributor.alternativeName | Jeong, Hyeon Joo | - |
dc.contributor.alternativeName | Kim, Pyung Kil | - |
dc.contributor.alternativeName | Kim, Ji Hong | - |
dc.contributor.alternativeName | Park, Se Jin | - |
dc.contributor.affiliatedAuthor | Kim, Ji Hong | - |
dc.contributor.affiliatedAuthor | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | Lee, Jae Seung | - |
dc.contributor.affiliatedAuthor | Lim, Beom Jin | - |
dc.contributor.affiliatedAuthor | Jeong, Hyeon Joo | - |
dc.contributor.affiliatedAuthor | Kim, Pyung Kil | - |
dc.contributor.affiliatedAuthor | Park, Se Jin | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 64 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 516 | - |
dc.citation.endPage | 519 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL PATHOLOGY, Vol.64(6) : 516-519, 2011 | - |
dc.identifier.rimsid | 28465 | - |
dc.type.rims | ART | - |
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