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Failure of complete recanalization is associated with poor outcome after cardioembolic stroke.

DC FieldValueLanguage
dc.contributor.author차명진-
dc.contributor.author최혜연-
dc.contributor.author허지회-
dc.contributor.author김영대-
dc.contributor.author남정모-
dc.contributor.author남효석-
dc.contributor.author이경열-
dc.contributor.author조현지-
dc.date.accessioned2014-12-20T16:59:13Z-
dc.date.available2014-12-20T16:59:13Z-
dc.date.issued2011-
dc.identifier.issn1351-5101-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93754-
dc.description.abstractBACKGROUND:   Recanalization is strongly associated with outcomes after thrombolytic treatment. Cardiac emboli are known as better response to fibrinolytic agents because they are fibrin-rich; however, cardioembolic stroke itself is associated with poor outcomes and high mortality. Completeness of recanalization may therefore affect the outcome of cardioembolic stroke. We investigated whether degree of recanalization influences outcomes following fibrinolytic therapy in cardioembolic stroke. METHODS:   Consecutive stroke patients with relevant artery occlusions on baseline CT angiography who had received thrombolytic treatment were enrolled. Completeness of recanalization was assessed by the Thrombolysis in Myocardial Infarction (TIMI) grade, which was compared between patients with and without cardiac sources of embolism (CSE). We also investigated independent predictors of poor outcome (modified Rankin scale score 3-6) at 3 months. RESULTS:   Of the 127 patients enrolled, 65 (51%) had one or more CSE. Although the overall recanalization rates (TIMI 2 or 3) in patients with CSE (65%) and patients without CSE (68%) were similar (P=0.710), patients with CSE were less likely to show complete recanalization (TIMI 3) compared with those without CSE (19% vs. 39%, P=0.011). Multivariate analysis revealed that CSE was associated with failure of complete recanalization (OR 2.809, 95% CI 1.097-7.192) and was an independent predictor of poor outcome at 3months (OR 3.629, 95% CI 1.205-8.869). CONCLUSIONS:   In cardioembolic strokes, failure of complete recanalization following thrombolytic therapy was frequent and was associated with poor outcome after thrombolysis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1171~1178-
dc.relation.isPartOfEUROPEAN JOURNAL OF NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAngiography, Digital Subtraction-
dc.subject.MESHFemale-
dc.subject.MESHHeart Diseases/complications-
dc.subject.MESHHumans-
dc.subject.MESHIntracranial Embolism/drug therapy-
dc.subject.MESHIntracranial Embolism/etiology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRecovery of Function*-
dc.subject.MESHRisk Factors-
dc.subject.MESHStroke/drug therapy*-
dc.subject.MESHStroke/pathology*-
dc.subject.MESHThrombolytic Therapy*-
dc.subject.MESHTissue Plasminogen Activator/therapeutic use-
dc.subject.MESHUrokinase-Type Plasminogen Activator/therapeutic use-
dc.titleFailure of complete recanalization is associated with poor outcome after cardioembolic stroke.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine (예방의학)-
dc.contributor.googleauthorH. S. Nam-
dc.contributor.googleauthorK.-Y. Lee-
dc.contributor.googleauthorY. D. Kim-
dc.contributor.googleauthorH.-Y. Choi-
dc.contributor.googleauthorH.-J. Cho-
dc.contributor.googleauthorM.-J. Cha-
dc.contributor.googleauthorC. M. Nam-
dc.contributor.googleauthorJ. H. Heo-
dc.identifier.doi10.1111/j.1468-1331.2011.03360.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03993-
dc.contributor.localIdA04217-
dc.contributor.localIdA04369-
dc.contributor.localIdA00702-
dc.contributor.localIdA01264-
dc.contributor.localIdA01273-
dc.contributor.localIdA02648-
dc.contributor.localIdA03932-
dc.relation.journalcodeJ00830-
dc.identifier.eissn1468-1331-
dc.identifier.pmid21309926-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1468-1331.2011.03360.x/abstract-
dc.subject.keywordcardiac embolism-
dc.subject.keywordcerebral infarction-
dc.subject.keywordprognosis-
dc.subject.keywordthrombolytic therapy-
dc.contributor.alternativeNameCha, Myoung Jin-
dc.contributor.alternativeNameChoi, Hye Yoen-
dc.contributor.alternativeNameHeo, Ji Hoe-
dc.contributor.alternativeNameKim, Young Dae-
dc.contributor.alternativeNameNam, Jung Mo-
dc.contributor.alternativeNameNam, Hyo Suk-
dc.contributor.alternativeNameLee, Kyung Yul-
dc.contributor.alternativeNameCho, Hyun Ji-
dc.contributor.affiliatedAuthorCha, Myoung Jin-
dc.contributor.affiliatedAuthorChoi, Hye Yoen-
dc.contributor.affiliatedAuthorHeo, Ji Hoe-
dc.contributor.affiliatedAuthorKim, Young Dae-
dc.contributor.affiliatedAuthorNam, Jung Mo-
dc.contributor.affiliatedAuthorNam, Hyo Suk-
dc.contributor.affiliatedAuthorLee, Kyung Yul-
dc.contributor.affiliatedAuthorCho, Hyun Ji-
dc.rights.accessRightsnot free-
dc.citation.volume18-
dc.citation.number9-
dc.citation.startPage1171-
dc.citation.endPage1178-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF NEUROLOGY, Vol.18(9) : 1171-1178, 2011-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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