Cited 13 times in
Evaluation of intratumoral HER-2 heterogeneity by fluorescence in situ hybridization in invasive breast cancer: a single institution study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구자승 | - |
dc.contributor.author | 정우희 | - |
dc.contributor.author | 홍순원 | - |
dc.date.accessioned | 2014-12-20T16:56:44Z | - |
dc.date.available | 2014-12-20T16:56:44Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93676 | - |
dc.description.abstract | This study aimed to determine the incidence and characteristics of HER-2 gene heterogeneity in invasive breast cancer in a single institution. Included were 971 cases of primary invasive breast cancer diagnosed between 2008 and 2010. Fluorescence in situ hybridization (FISH) image files were retrospectively reviewed and HER-2 gene heterogeneity was defined as more than 5% but less than 50% of analyzed invasive tumor cells with a HER-2/Chr17 ratio higher than 2.2, according to the College of American Pathologists guidelines. HER-2 gene heterogeneity was identified in 24 (2.5%) cases. The mean proportion of invasive tumor cells with a HER-2/chromosome 17 ratio higher than 2.2 was 11.6% (range: 5%-25%). Of 24 cases, HER-2 gene status was not amplified in 8, showed borderline amplification in 2, and amplification in 14. All HER-2 amplification cases were low-grade. In conclusion, HER-2 gene heterogeneity of invasive breast cancer is identified in routine FISH examination. This may affect the results of HER-2 gene amplification status in FISH studies. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1001~1006 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Breast Neoplasms/genetics* | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Chromosomes, Human, Pair 17 | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genetic Heterogeneity | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization, Fluorescence/methods* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Receptor, ErbB-2/genetics* | - |
dc.subject.MESH | Receptor, ErbB-2/metabolism | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Evaluation of intratumoral HER-2 heterogeneity by fluorescence in situ hybridization in invasive breast cancer: a single institution study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Sarah Lee | - |
dc.contributor.googleauthor | Woohee Jung | - |
dc.contributor.googleauthor | Soon-Won Hong | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.3346/jkms.2011.26.8.1001 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A03671 | - |
dc.contributor.localId | A04411 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 21860549 | - |
dc.subject.keyword | Breast Neoplasms | - |
dc.subject.keyword | HER-2 | - |
dc.subject.keyword | Gene Heterogeneity | - |
dc.subject.keyword | In Situ Hybridization | - |
dc.subject.keyword | Fluorescence | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.alternativeName | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 26 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1001 | - |
dc.citation.endPage | 1006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.26(8) : 1001-1006, 2011 | - |
dc.identifier.rimsid | 28386 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.