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Uncovered primary seizure foci in Lennox-Gastaut syndrome after corpus callosotomy

DC FieldValueLanguage
dc.contributor.author강훈철-
dc.contributor.author김동석-
dc.contributor.author김흥동-
dc.contributor.author이준수-
dc.date.accessioned2014-12-20T16:56:21Z-
dc.date.available2014-12-20T16:56:21Z-
dc.date.issued2011-
dc.identifier.issn0387-7604-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93664-
dc.description.abstractPURPOSE: Corpus callosotomy (CC) is a palliative surgical procedure to control atonic, tonic, or generalized tonic-clonic seizure in Lennox-Gastaut syndrome (LGS). Here, we report patients with LGS who underwent resective surgery, following CC better delineating the presumed seizure foci localized in one hemisphere. METHODS: We retrospectively reviewed seven patients with LGS who underwent CC and subsequent cortical resection. The median follow-up duration after lobectomy was 20 months (range, 15-54 months) and three patients had follow-up periods over 24 months. The findings of video electroencephalography (EEG) monitoring, structural and functional neuroimagings were compared between pre- and post-CC. RESULTS: Four patients had Engel class I and one patient had Engel class II outcomes following cortical resection; post-CC, compared to pre-CC, showed better localized ictal/interictal epileptiform discharges in the unilateral frontal area in two patients, in the unilateral parieto-temporo-occipital areas in one patient and in the unilateral fronto-temporal areas in the remaining two patients. Two patients had Engel Class III outcome following cortical resection; post-CC EEG continued to show multifocal epileptiform discharges but predominantly arising from a unilateral frontal area. Following CC, positron emission tomography showed localized glucose hypometabolism of which location was concordant with post-CC EEG abnormalities in all patient. Similarly, ictal/interictal single photon emission computed tomography also showed localized abnormalities concordant with post-CC EEG abnormalities in five of the six patients. Pathological assessment revealed cortical dysplasia in six patients, whereas no pathological abnormality was found in the remaining patient, who obtained Engel Class I outcome following cortical resection. CONCLUSION: CC could change EEG findings, glucose metabolisms and cerebral blood flows, and it is sometimes helpful in delineating the primary seizure focus in patients with LGS.-
dc.description.statementOfResponsibilityopen-
dc.format.extent672~677-
dc.relation.isPartOfBRAIN & DEVELOPMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHCorpus Callosum/surgery*-
dc.subject.MESHElectroencephalography-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHIntellectual Disability/pathology*-
dc.subject.MESHIntellectual Disability/physiopathology-
dc.subject.MESHIntellectual Disability/surgery*-
dc.subject.MESHLennox Gastaut Syndrome-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSeizures/physiopathology-
dc.subject.MESHSeizures/surgery*-
dc.subject.MESHSpasms, Infantile/pathology*-
dc.subject.MESHSpasms, Infantile/physiopathology-
dc.subject.MESHSpasms, Infantile/surgery*-
dc.titleUncovered primary seizure foci in Lennox-Gastaut syndrome after corpus callosotomy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorYun Jung Hur-
dc.contributor.googleauthorHoon-Chul Kang-
dc.contributor.googleauthorDong Seok Kim-
dc.contributor.googleauthorSae Rom Choi-
dc.contributor.googleauthorHeung Dong Kim-
dc.contributor.googleauthorJoon Soo Lee-
dc.identifier.doi10.1016/j.braindev.2010.11.005-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00102-
dc.contributor.localIdA00402-
dc.contributor.localIdA01208-
dc.contributor.localIdA03177-
dc.relation.journalcodeJ00386-
dc.identifier.eissn1872-7131-
dc.identifier.pmid21146944-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0387760410002925-
dc.subject.keywordLennox–Gastaut syndrome-
dc.subject.keywordCorpus callosotomy-
dc.subject.keywordPrimary seizure foci-
dc.contributor.alternativeNameKang, Hoon Chul-
dc.contributor.alternativeNameKim, Dong Seok-
dc.contributor.alternativeNameKim, Heung Dong-
dc.contributor.alternativeNameLee, Joon Soo-
dc.contributor.affiliatedAuthorKang, Hoon Chul-
dc.contributor.affiliatedAuthorKim, Dong Seok-
dc.contributor.affiliatedAuthorKim, Heung Dong-
dc.contributor.affiliatedAuthorLee, Joon Soo-
dc.rights.accessRightsnot free-
dc.citation.volume33-
dc.citation.number8-
dc.citation.startPage672-
dc.citation.endPage677-
dc.identifier.bibliographicCitationBRAIN & DEVELOPMENT, Vol.33(8) : 672-677, 2011-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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