Cited 11 times in
Comparison of treatment outcome between breast-conservation surgery with radiation and total mastectomy without radiation in patients with one to three positive axillary lymph nodes
DC Field | Value | Language |
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dc.contributor.author | 김승일 | - |
dc.contributor.author | 김용배 | - |
dc.contributor.author | 박병우 | - |
dc.contributor.author | 박세호 | - |
dc.contributor.author | 박형석 | - |
dc.contributor.author | 서창옥 | - |
dc.date.accessioned | 2014-12-20T16:54:22Z | - |
dc.date.available | 2014-12-20T16:54:22Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93602 | - |
dc.description.abstract | PURPOSE: To test the difference in treatment outcome between breast-conservation surgery with radiation and total mastectomy without radiation, to evaluate the benefits of adjuvant radiotherapy in patients with one to three positive axillary lymph nodes. METHODS AND MATERIALS: Using the Severance Hospital Breast Cancer Registry, we divided the study population of T1, T2 and one to three axillary node-positive patients into two groups: breast-conservation surgery with radiation (BCS/RT) and total mastectomy without radiation (TM/no-RT). Data related to locoregional recurrence, distant recurrence, and death were collected, and survival rates were calculated. RESULTS: The study population consisted of 125 patients treated with BCS/RT and 365 patients treated with TM/no-RT. With a median follow-up of 68.4 months, the 10-year locoregional recurrence-free survival rate with BCS/RT and TM/no-RT was 90.5% and 79.2%, respectively (p = 0.056). The 10-year distant recurrence-free survival rate was 78.8% for patients treated with BCS/RT vs. 68.0% for those treated with TM/no-RT (p = 0.012). The 10-years overall survival rate for patients treated with BCT/RT and TM/no-RT was 87.5% and 73.9%, respectively (p = 0.035). After multivariate analysis, patients treated with BCT/RT had better distant recurrence-free survival (hazard ratio [HR], 0.527; 95% confidence interval [CI], 0.297-0.934; p = 0.028), with improving locoregional recurrence-free survival (HR, 0.491; 95% CI, 0.231-1.041; p = 0.064) and overall survival trend (HR, 0.544; 95% CI, 0.277-1.067; p = 0.076). CONCLUSIONS: This study provides additional evidence that adjuvant radiation substantially reduces local recurrence, distant recurrence, and mortality for patients with one to three involved nodes. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1446~1452 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Breast Neoplasms*/chemistry | - |
dc.subject.MESH | Breast Neoplasms*/mortality | - |
dc.subject.MESH | Breast Neoplasms*/pathology | - |
dc.subject.MESH | Breast Neoplasms*/prevention & control | - |
dc.subject.MESH | Breast Neoplasms*/radiotherapy | - |
dc.subject.MESH | Breast Neoplasms*/surgery | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Mastectomy, Segmental/methods | - |
dc.subject.MESH | Mastectomy, Segmental/mortality | - |
dc.subject.MESH | Mastectomy, Simple/methods | - |
dc.subject.MESH | Mastectomy, Simple/mortality | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Neoplasm Recurrence, Local/mortality | - |
dc.subject.MESH | Neoplasm Recurrence, Local/prevention & control | - |
dc.subject.MESH | Radiotherapy Dosage | - |
dc.subject.MESH | Radiotherapy, Adjuvant/methods | - |
dc.subject.MESH | Radiotherapy, Adjuvant/mortality | - |
dc.subject.MESH | Receptors, Estrogen/analysis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Comparison of treatment outcome between breast-conservation surgery with radiation and total mastectomy without radiation in patients with one to three positive axillary lymph nodes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Seung Il Kim | - |
dc.contributor.googleauthor | Seho Park | - |
dc.contributor.googleauthor | Hyung Seok Park | - |
dc.contributor.googleauthor | Yong Bae Kim | - |
dc.contributor.googleauthor | Chang Ok Suh | - |
dc.contributor.googleauthor | Byeong-Woo Park | - |
dc.identifier.doi | 10.1016/j.ijrobp.2010.04.051 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00744 | - |
dc.contributor.localId | A00658 | - |
dc.contributor.localId | A01475 | - |
dc.contributor.localId | A01524 | - |
dc.contributor.localId | A01753 | - |
dc.contributor.localId | A01919 | - |
dc.relation.journalcode | J01157 | - |
dc.identifier.eissn | 1879-355X | - |
dc.identifier.pmid | 20598451 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0360301610006644 | - |
dc.subject.keyword | Breast-conservation surgery | - |
dc.subject.keyword | Total mastectomy | - |
dc.subject.keyword | RadiationN1 disease | - |
dc.subject.keyword | Survival | - |
dc.contributor.alternativeName | Kim, Seung Il | - |
dc.contributor.alternativeName | Kim, Yong Bae | - |
dc.contributor.alternativeName | Park, Byeong Woo | - |
dc.contributor.alternativeName | Park, Se Ho | - |
dc.contributor.alternativeName | Park, Hyung Seok | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.affiliatedAuthor | Kim, Yong Bae | - |
dc.contributor.affiliatedAuthor | Kim, Seung Il | - |
dc.contributor.affiliatedAuthor | Park, Byeong Woo | - |
dc.contributor.affiliatedAuthor | Park, Se Ho | - |
dc.contributor.affiliatedAuthor | Park, Hyung Seok | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 80 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1446 | - |
dc.citation.endPage | 1452 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.80(5) : 1446-1452, 2011 | - |
dc.identifier.rimsid | 28335 | - |
dc.type.rims | ART | - |
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