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Magnesium sulfate prevents remifentanil-induced postoperative hyperalgesia in patients undergoing thyroidectomy.

DC Field Value Language
dc.contributor.author송종욱-
dc.contributor.author심연희-
dc.contributor.author윤경봉-
dc.contributor.author이윤우-
dc.contributor.author박수정-
dc.date.accessioned2014-12-20T16:53:50Z-
dc.date.available2014-12-20T16:53:50Z-
dc.date.issued2011-
dc.identifier.issn0003-2999-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93585-
dc.description.abstractBACKGROUND: In a randomized, double-blind, prospective study, we investigated whether an intraoperative high versus low dose of remifentanil increased postoperative hyperalgesia and whether magnesium can prevent remifentanil-induced hyperalgesia. METHODS: Ninety patients undergoing thyroidectomy were randomly assigned to 1 of 3 groups. Remifentanil was intraoperatively infused at 0.05 μg/kg/min (group LO) or 0.2 μg/kg/min (groups HI and HM). Patients in group HM received MgSO(4) 30 mg/kg at induction followed by an intraoperative infusion of 10 mg/kg/h. Mechanical pain thresholds on the forearm and periincisional area were assessed by von Frey filament the evening before surgery and postoperatively at 24 and 48 hours. Pain measured on a verbal numerical rating scale (VNRS) (0-10) and additional analgesics were recorded in the postanesthesia care unit postoperatively at 6, 24, and 48 hours. RESULTS: There was a significantly greater decrease in pain threshold on the periincisional area at 24 and 48 hours postoperatively in group HI, as compared with the other 2 groups. The 95% confidence intervals for the mean difference in pain thresholds on the periincisional area at 24 and 48 hours postoperatively were 0.31 to 1.11 and 0.36 to 1.14 for group HI versus group LO, 0.45 to 1.26 and 0.54 to 1.32 for group HI versus group HM (values are log(10) of force in milligrams). The change in pain threshold on the forearm was similar among the groups. Group HI had significantly higher VNRS scores (median [interquartile range], 3 [2-4]) than group LO (2 [1-3] and group HM (2 [1-3]) at 48 hours postoperatively. The 95% confidence intervals for median difference in VNRS score at 48 hours postoperatively were 1 to 2 for group HI versus group LO and 0 to 2 for group HI versus group HM. There were no significant differences in the number of patients who requested rescue analgesics in the postoperative anesthesia care unit and general ward during 48 hours postoperatively among the 3 groups. CONCLUSIONS: A relatively high dose of intraoperative remifentanil enhances periincisional hyperalgesia. Intraoperative MgSO(4) prevents remifentanil-induced hyperalgesia. However, hyperalgesia did not reach clinical relevance in terms of postoperative pain or analgesic consumption in patients undergoing thyroidectomy.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfANESTHESIA AND ANALGESIA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnalgesics/administration & dosage-
dc.subject.MESHAnesthesia Recovery Period-
dc.subject.MESHAnesthesia, General-
dc.subject.MESHAnesthetics, Intravenous/administration & dosage-
dc.subject.MESHAnesthetics, Intravenous/adverse effects*-
dc.subject.MESHAnesthetics, Intravenous/antagonists & inhibitors-
dc.subject.MESHBlood Pressure/drug effects-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHFemale-
dc.subject.MESHHeart Rate/drug effects-
dc.subject.MESHHumans-
dc.subject.MESHHyperalgesia/prevention & control*-
dc.subject.MESHMagnesium Sulfate/adverse effects-
dc.subject.MESHMagnesium Sulfate/therapeutic use*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPain Measurement-
dc.subject.MESHPain Threshold/drug effects-
dc.subject.MESHPain, Postoperative/prevention & control*-
dc.subject.MESHPhysical Stimulation-
dc.subject.MESHPiperidines/administration & dosage-
dc.subject.MESHPiperidines/adverse effects*-
dc.subject.MESHPiperidines/antagonists & inhibitors-
dc.subject.MESHRecovery Room-
dc.subject.MESHThyroidectomy/adverse effects*-
dc.subject.MESHYoung Adult-
dc.titleMagnesium sulfate prevents remifentanil-induced postoperative hyperalgesia in patients undergoing thyroidectomy.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorSong, Jong Wook-
dc.contributor.googleauthorLee, Youn-Woo-
dc.contributor.googleauthorYoon, Kyung Bong-
dc.contributor.googleauthorPark, Soo Jung-
dc.contributor.googleauthorShim, Yon Hee-
dc.identifier.doi10.1213/ANE.0b013e31821d72bc-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02060-
dc.contributor.localIdA02196-
dc.contributor.localIdA02539-
dc.contributor.localIdA03022-
dc.relation.journalcodeJ00144-
dc.identifier.eissn1526-7598-
dc.identifier.pmid21596876-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000539-201108000-00030&LSLINK=80&D=ovft-
dc.contributor.alternativeNameSong, Jong Wook-
dc.contributor.alternativeNameShim, Yon Hee-
dc.contributor.alternativeNameYoon, Kyoung Bong-
dc.contributor.alternativeNameLee, Youn Woo-
dc.contributor.affiliatedAuthorSong, Jong Wook-
dc.contributor.affiliatedAuthorShim, Yon Hee-
dc.contributor.affiliatedAuthorYoon, Kyoung Bong-
dc.contributor.affiliatedAuthorLee, Youn Woo-
dc.rights.accessRightsnot free-
dc.citation.volume113-
dc.citation.number2-
dc.citation.startPage390-
dc.citation.endPage397-
dc.identifier.bibliographicCitationANESTHESIA AND ANALGESIA, Vol.113(2) : 390-397, 2011-
dc.identifier.rimsid28326-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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