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Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging.

Authors
 Eun-Kyung Lim ; Hyun-Ouk Kim ; Seungjoo Haam ; Yong-Min Huh ; Jin-Suck Suh ; Kwangyeol Lee ; Joseph Park ; Eunji Jang 
Citation
 Biomaterials, Vol.32(31) : 7941~7950, 2011 
Journal Title
 Biomaterials 
ISSN
 0142-9612 
Issue Date
2011
Abstract
We fabricated hyaluronan-modified magnetic nanoclusters (HA-MNCs) for detection of CD44-overexpressing breast cancer using magnetic resonance (MR) imaging. CD44 is closely associated with cancer growth, including proliferation, metastasis, invasion, and angiogenesis. Hence, pyrenyl hyaluronan (Py-HA) conjugates were synthesized as CD44-targetable surfactants with hyaluronan (HA) and 1-pyrenylbutyric acid (Py) to modify hyaluronan on hydrophobic magnetic nanocrystals. Subsequently, HA-MNCs were fabricated using the nano-emulsion method; magnetic nanocrystals were simultaneously self-assembled with Py-HA conjugates, and their physical and magnetic properties depended on the degree of substitution (DS) of Py in Py-HA conjugates. HA-MNCs exhibited superior targeting efficiency with MR sensitivity as well as excellent biocompatibility through in vitro/in vivo studies. This suggests that HA-MNCs can be a potent cancer specific molecular imaging agent via targeted detection of CD44 with MR imaging.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93561
DOI
10.1016/j.biomaterials.2011.06.077
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0142961211007708
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