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Effects of multiple drilling on the ischemic capital femoral epiphysis of immature piglets

 Sun Young Gong  ;  Hyun Woo Kim  ;  Hui-Wan Park  ;  Seung Yup Lee  ;  Ki Seok Lee 
 YONSEI MEDICAL JOURNAL, Vol.52(5) : 809-817, 2011 
Journal Title
Issue Date
Animals ; Bone Remodeling ; Disease Models, Animal ; Epiphyses/blood supply* ; Epiphyses/pathology ; Epiphyses/surgery* ; Female ; Femur Head/blood supply* ; Femur Head/pathology ; Femur Head/surgery* ; Humans ; Ischemia/pathology ; Ischemia/surgery* ; Legg-Calve-Perthes Disease/pathology ; Legg-Calve-Perthes Disease/surgery ; Swine
LCP disease ; multiple drilling ; revascularization ; head collapse
PURPOSE: This study investigated the effects of multiple drilling on the immature capital femoral epiphysis following ischemic injury in a piglet model. MATERIALS AND METHODS: Ischemic necrosis of capital femoral epiphysis was induced bilaterally in 12 piglets using a cervical ligation method. Three weeks later, medial, central, and lateral 3 drill holes were made on the left femoral head using 0.062" K-wire. At 3, 6, 9, and 12 weeks following the multiple drilling, femoral heads were harvested from each three piglets. On histologic examination, percent of revascularization, percent of osteoblast surface, capital femoral epiphyseal quotient and proximal femoral growth plate height were evaluated. Untreated right femoral heads served as control. RESULTS: While percent of revascularization of left capital femoral epiphysis with multiple drilling was significantly higher than untreated control side (p<0.001), percent of osteoblast surface, capital femoral epiphyseal quotient and proximal femoral growth plate height showed no significant difference. CONCLUSION: This study indicates that multiple drilling could promote revascularization of ischemic capital femoral epiphysis, and multiple drilling does not appear to produce bony physeal bars at short-term, if using small diameter drill. However, multiple drilling alone does not seem to prevent femoral head deformity or to promote new bone formation.
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1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kong, Sun Young(공선영)
Kim, Hyun Woo(김현우) ORCID logo https://orcid.org/0000-0001-8576-1877
Park, Hui Wan(박희완)
Lee, Ki Seok(이기석)
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