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Acquisition of extensive drug-resistant Pseudomonas aeruginosa among hospitalized patients: risk factors and resistance mechanisms to carbapenems

DC FieldValueLanguage
dc.contributor.author김준명-
dc.contributor.author이경원-
dc.contributor.author정석훈-
dc.contributor.author진범식-
dc.contributor.author한상훈-
dc.date.accessioned2014-12-20T16:51:31Z-
dc.date.available2014-12-20T16:51:31Z-
dc.date.issued2011-
dc.identifier.issn0195-6701-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93512-
dc.description.abstractExtensive drug-resistant Pseudomonas aeruginosa (XDRPA) strains, defined as resistant to all available antipseudomonal antibiotics, have been reported recently. This study aimed to investigate the risk factors for XDRPA acquisition by patients and the resistance mechanisms to carbapenems. From June to November 2007, XDRPA isolates were collected from patients in eight tertiary care hospitals. A case-control study was performed to determine factors associated with XDRPA acquisition. EDTA-imipenem disc synergy tests, and polymerase chain reaction amplification and sequencing were performed to detect the presence of metallo-β-lactamases (MBLs). Risk factor analysis was performed for 33 patients. Mechanical ventilation [odds ratio (OR) 8.2, 95% confidence interval (CI) 1.3-52.2; P = 0.026] and APACHE II score (OR 1.2, 95% CI 1.0-1.3; P = 0.007) were identified as independent risk factors for XDRPA acquisition. Pulsed-field gel electrophoresis of XDRPA identified clonal epidemic isolates co-existing with sporadic isolates. Eight of 43 (19%) XDRPA isolates were shown to produce MBLs; four produced VIM-2 and four produced IMP-6. This study suggests a major role for mechanical ventilation in XDRPA acquisition. Moreover, pulsed-field gel electrophoresis identified a clonal epidemic within hospitals. Taken together, these results suggest that patient-to-patient transmission contributes to XDRPA acquisition in Korea-
dc.description.statementOfResponsibilityopen-
dc.format.extent54~58-
dc.relation.isPartOfJournal of Hospital Infection-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAnti-Bacterial Agents/pharmacology-
dc.subject.MESHCarbapenems/pharmacology*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHDrug Resistance, Multiple, Bacterial*-
dc.subject.MESHFemale-
dc.subject.MESHHospitals-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPseudomonas Infections/epidemiology*-
dc.subject.MESHPseudomonas Infections/microbiology*-
dc.subject.MESHPseudomonas aeruginosa/enzymology*-
dc.subject.MESHPseudomonas aeruginosa/isolation & purification-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRespiration, Artificial/adverse effects-
dc.subject.MESHRisk Factors-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHbeta-Lactamases/biosynthesis*-
dc.titleAcquisition of extensive drug-resistant Pseudomonas aeruginosa among hospitalized patients: risk factors and resistance mechanisms to carbapenems-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorY.S. Park-
dc.contributor.googleauthorH. Lee-
dc.contributor.googleauthorB.S. Chin-
dc.contributor.googleauthorS.H. Han-
dc.contributor.googleauthorS.G. Hong-
dc.contributor.googleauthorS.K. Hong-
dc.contributor.googleauthorH.Y. Kim-
dc.contributor.googleauthorY. Uh-
dc.contributor.googleauthorH.B. Shin-
dc.contributor.googleauthorE.J. Choo-
dc.contributor.googleauthorS.-H. Han-
dc.contributor.googleauthorW. Song-
dc.contributor.googleauthorS.H. Jeong-
dc.contributor.googleauthorK. Lee-
dc.contributor.googleauthorJ.M. Kim-
dc.identifier.doi10.1016/j.jhin.2011.05.014-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00953-
dc.contributor.localIdA02649-
dc.contributor.localIdA03619-
dc.contributor.localIdA03981-
dc.contributor.localIdA04286-
dc.relation.journalcodeJ01445-
dc.identifier.pmid21764173-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0195670111002544-
dc.subject.keywordCarbapenem resistance-
dc.subject.keywordExtensive drug resistance-
dc.subject.keywordPseudomonas aeruginosa-
dc.subject.keywordRisk factor-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.alternativeNameJeong, Seok Hoon-
dc.contributor.alternativeNameChin, Bum Sik-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorJeong, Seok Hoon-
dc.contributor.affiliatedAuthorChin, Bum Sik-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.rights.accessRightsnot free-
dc.citation.volume79-
dc.citation.number1-
dc.citation.startPage54-
dc.citation.endPage58-
dc.identifier.bibliographicCitationJournal of Hospital Infection, Vol.79(1) : 54-58, 2011-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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