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Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassays.

DC FieldValueLanguage
dc.contributor.author김한수-
dc.contributor.author김현옥-
dc.contributor.author박성하-
dc.contributor.author윤종찬-
dc.date.accessioned2014-12-20T16:51:18Z-
dc.date.available2014-12-20T16:51:18Z-
dc.date.issued2011-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93505-
dc.description.abstractBACKGROUND: Lipid metabolites and cytokines, including chemokines and growth factors, are the key regulators of immune cell function and differentiation, and thus, dysregulation of these regulators is associated with various human diseases. However, previous studies demonstrating a positive correlation of cytokine levels with aging may have been influenced by various environmental factors and underlying diseases. Also, data regarding cytokine profiling in the elderly are limited to a small subset of cytokines. METHODS: We compared the profiles of 22 cytokines, including chemokines and growth factors, in a case-controlled study group of a gender-matched, healthy cohort of 55 patients over the age of 65 and 55 patients under the age of 45. Assessment of serum cytokine concentrations was performed using commercially-available multiplex bead-based sandwich immunoassays. RESULTS: Soluble CD40 ligand (sCD40L) and transforming growth factor alpha (TGF-α) levels were significantly higher in the elderly patients, whereas granulocyte colony-stimulating factor (G-CSF), granulocyte-monocyte colony-stimulating factor (GM-CSF), and monocyte chemoattractant protein-1 (MCP-1) levels were significantly lower in the elderly patients. The partial correlation analysis demonstrating the correlation between cytokine levels when controlled for gender, systolic blood pressure, total cholesterol, HDL cholesterol, triglyceride, and serum creatinine levels further demonstrated that G-CSF, GM-CSF, and MCP-1 had significant negative correlations with age, whereas sCD40L and TGF-α had significant positive correlations. CONCLUSIONS: Future studies will focus on examining the significance of these age-related changes in circulating cytokines and other biological markers and their potential contribution to the development of different age-associated diseases-
dc.description.statementOfResponsibilityopen-
dc.format.extent113-
dc.relation.isPartOfJOURNAL OF TRANSLATIONAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAging/blood*-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHBlood Glucose/metabolism-
dc.subject.MESHBlood Pressure/physiology-
dc.subject.MESHBody Mass Index-
dc.subject.MESHChemokines/blood-
dc.subject.MESHCholesterol/blood-
dc.subject.MESHCreatinine/blood-
dc.subject.MESHCytokines/blood*-
dc.subject.MESHFemale-
dc.subject.MESHHealth*-
dc.subject.MESHHumans-
dc.subject.MESHImmunoassay/methods*-
dc.subject.MESHIntercellular Signaling Peptides and Proteins/blood-
dc.subject.MESHMale-
dc.subject.MESHMicrospheres*-
dc.subject.MESHSmoking/blood-
dc.subject.MESHTriglycerides/blood-
dc.titleSerum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassays.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHyun Ok Kim-
dc.contributor.googleauthorHan-Soo Kim-
dc.contributor.googleauthorJong-Chan Youn-
dc.contributor.googleauthorEui-Cheol Shin-
dc.contributor.googleauthorSungha Park-
dc.identifier.doi10.1186/1479-5876-9-113-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01100-
dc.contributor.localIdA01122-
dc.contributor.localIdA01512-
dc.contributor.localIdA02600-
dc.relation.journalcodeJ01915-
dc.identifier.eissn1479-5876-
dc.identifier.pmid21774806-
dc.subject.keywordVascular Endothelial Growth Factor-
dc.subject.keywordPartial Correlation Analysis-
dc.subject.keywordHigh Systolic Blood Pressure-
dc.subject.keywordImmune Cell Function-
dc.subject.keywordSerum Blood Urea Nitrogen-
dc.contributor.alternativeNameKim, Han Soo-
dc.contributor.alternativeNameKim, Hyun Ok-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNameYoun, Jong Chan-
dc.contributor.affiliatedAuthorKim, Han Soo-
dc.contributor.affiliatedAuthorKim, Hyun Ok-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorYoun, Jong Chan-
dc.rights.accessRightsfree-
dc.citation.volume9-
dc.citation.startPage113-
dc.identifier.bibliographicCitationJOURNAL OF TRANSLATIONAL MEDICINE, Vol.9 : 113, 2011-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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