Cited 10 times in
Comparative proteomic analysis of advanced serous epithelial ovarian carcinoma: possible predictors of chemoresistant disease
DC Field | Value | Language |
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dc.contributor.author | 김성훈 | - |
dc.contributor.author | 김영태 | - |
dc.contributor.author | 김재훈 | - |
dc.contributor.author | 남은지 | - |
dc.contributor.author | 백지흠 | - |
dc.contributor.author | 이산희 | - |
dc.contributor.author | 정용욱 | - |
dc.contributor.author | 김상운 | - |
dc.date.accessioned | 2014-12-20T16:49:41Z | - |
dc.date.available | 2014-12-20T16:49:41Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1536-2310 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93454 | - |
dc.description.abstract | To identify specific proteins associated with chemotherapeutic responses, we analyzed protein expression patterns in stage IIIc primary serous epithelial ovarian cancer tissues displaying differential responses to first-line postoperative adjuvant chemotherapy. The expression profiles of five chemoresistant tissues [progression-free survival (PFS) ≤12 months] and five chemosensitive tissues (PFS ≥48 months) were analyzed with 2D electrophoresis, and the spot intensities of differentially expressed proteins were quantified. To validate these proteins as markers for chemoresistant disease, we analyzed tissues from an additional 17 patients. All the patients were allocated to the over- or underexpressing group according to protein spot intensity, and survival analysis was performed. In chemoresistant tissues, four proteins (thioredoxin domain containing four, similar to RIKEN cDNA 1700016G05, tubulin α 1A chain, and the pyruvate dehydrogenase E1-β subunit precursor) were overexpressed, and seven proteins [keratin 1, vitamin D-binding protein, creatine kinase B, annexin V, SH3-containing guanine nucleotide exchange factor (SGEF), tryptophan-aspartate repeat protein-1 (WDR 1), and WDR 1 isoform 1] were underexpressed. The underexpression of keratin 1, creatine kinase B, annexin V, SGEF, WDR1, and WDR1 isoform 1 were significantly correlated with poor overall survival. A combination of keratin 1 and SGEF showed the highest sensitivity of 0.800, specificity of 0.917, PPV of 0.800, and NPV of 0.917 in predicting chemoresistant disease. These proteins may be useful as predictive markers of chemoresistant disease. However, further analyses in large-scale should be performed before they can be considered reliable predictive markers of chemoresistant disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 281~292 | - |
dc.relation.isPartOf | OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cystadenocarcinoma, Serous/genetics | - |
dc.subject.MESH | Cystadenocarcinoma, Serous/metabolism* | - |
dc.subject.MESH | Cystadenocarcinoma, Serous/pathology | - |
dc.subject.MESH | Drug Resistance, Neoplasm/genetics* | - |
dc.subject.MESH | Electrophoresis, Gel, Two-Dimensional | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Profiling | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic/genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Ovarian Neoplasms/genetics | - |
dc.subject.MESH | Ovarian Neoplasms/metabolism* | - |
dc.subject.MESH | Ovarian Neoplasms/pathology | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proteomics* | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Survival Analysis | - |
dc.title | Comparative proteomic analysis of advanced serous epithelial ovarian carcinoma: possible predictors of chemoresistant disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Sang Wun Kim | - |
dc.contributor.googleauthor | Sunghoon Kim | - |
dc.contributor.googleauthor | Eun Ji Nam | - |
dc.contributor.googleauthor | Yong Wook Jeong | - |
dc.contributor.googleauthor | San Hui Lee | - |
dc.contributor.googleauthor | Ji Heum Paek | - |
dc.contributor.googleauthor | Jae Hoon Kim | - |
dc.contributor.googleauthor | Jae Wook Kim | - |
dc.contributor.googleauthor | Young Tae Kim | - |
dc.identifier.doi | 10.1089/omi.2010.0012 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00595 | - |
dc.contributor.localId | A00729 | - |
dc.contributor.localId | A00876 | - |
dc.contributor.localId | A01262 | - |
dc.contributor.localId | A01840 | - |
dc.contributor.localId | A02808 | - |
dc.contributor.localId | A03661 | - |
dc.contributor.localId | A00526 | - |
dc.relation.journalcode | J02412 | - |
dc.identifier.eissn | 1557-8100 | - |
dc.identifier.pmid | 21332407 | - |
dc.identifier.url | http://online.liebertpub.com/doi/abs/10.1089/omi.2010.0012 | - |
dc.contributor.alternativeName | Kim, Sung Hoon | - |
dc.contributor.alternativeName | Kim, Young Tae | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.alternativeName | Nam, Eun Ji | - |
dc.contributor.alternativeName | Paek, Ji Heum | - |
dc.contributor.alternativeName | Lee, San Hui | - |
dc.contributor.alternativeName | Jung, Yong Wook | - |
dc.contributor.alternativeName | Kim, Sang Wun | - |
dc.contributor.affiliatedAuthor | Kim, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Young Tae | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Nam, Eun Ji | - |
dc.contributor.affiliatedAuthor | Paek, Ji Heum | - |
dc.contributor.affiliatedAuthor | Lee, San Hui | - |
dc.contributor.affiliatedAuthor | Jung, Yong Wook | - |
dc.contributor.affiliatedAuthor | Kim, Sang Wun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 15 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 281 | - |
dc.citation.endPage | 292 | - |
dc.identifier.bibliographicCitation | OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, Vol.15(5) : 281-292, 2011 | - |
dc.identifier.rimsid | 28244 | - |
dc.type.rims | ART | - |
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