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Ambidextrous magnetic nanovectors for synchronous gene transfection and labeling of human MSCs

Authors
 Jaemoon Yang  ;  Eun-Sook Lee  ;  Yong-Min Huh  ;  Seungjoo Haam  ;  Seung Hyun Kim  ;  Jin-Suck Suh  ;  Kwangyeol Lee  ;  A-Rum Yoo  ;  Eun-Kyung Lim  ;  Seong-Ho Koh  ;  Min-Young Noh 
Citation
 Biomaterials, Vol.32(26) : 6174-6182, 2011 
Journal Title
 Biomaterials 
ISSN
 0142-9612 
Issue Date
2011
Abstract
The synchronization of gene expression and cell trafficking in transfected stem cells is crucial for augmentation of stem cell functions (differentiation and neurotropic factor secretion) and real time in vivo monitoring. We report a magnetic nanoparticle-based gene delivery system that can ensure simultaneous gene delivery and in vivo cell trafficking by high resolution MR imaging. The polar aprotic solvent soluble MnFe₂O₄ nanoparticles were enveloped using cationic polymers (branched polyethyleneimine, PEI) by the solvent shifting method for a gene loading. Using our magnetic nanovector system (PEI-coated MnFe₂O₄ nanoparticles), thus, we synchronized stem cell migration and its gene expression in a rat stroke mod
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93439
DOI
10.1016/j.biomaterials.2011.04.007
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
서진석(Suh, Jin Suck) ; 양재문(Yang, Jae Moon) ; 허용민(Huh, Yong Min)
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Full Text
http://www.sciencedirect.com/science/article/pii/S0142961211003899
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