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Ambidextrous magnetic nanovectors for synchronous gene transfection and labeling of human MSCs

Authors
 Jaemoon Yang  ;  Eun-Sook Lee  ;  Min-Young Noh  ;  Seong-Ho Koh  ;  Eun-Kyung Lim  ;  A-Rum Yoo  ;  Kwangyeol Lee  ;  Jin-Suck Suh  ;  Seung Hyun Kim  ;  Seungjoo Haam  ;  Yong-Min Huh 
Citation
 BIOMATERIALS, Vol.32(26) : 6174-6182, 2011 
Journal Title
 BIOMATERIALS 
ISSN
 0142-9612 
Issue Date
2011
MeSH
Animals ; Cells, Cultured ; Genetic Vectors/chemistry* ; Humans ; Immunohistochemistry ; Magnetics* ; Mesenchymal Stromal Cells/chemistry ; Mesenchymal Stromal Cells/metabolism* ; Nanoparticles/chemistry* ; Rats ; Spectroscopy, Fourier Transform Infrared ; Transfection/methods*
Keywords
Magnetic ; Nanovectors ; Gene deliveryStem cell ; Solvent shifting
Abstract
The synchronization of gene expression and cell trafficking in transfected stem cells is crucial for augmentation of stem cell functions (differentiation and neurotropic factor secretion) and real time in vivo monitoring. We report a magnetic nanoparticle-based gene delivery system that can ensure simultaneous gene delivery and in vivo cell trafficking by high resolution MR imaging. The polar aprotic solvent soluble MnFe₂O₄ nanoparticles were enveloped using cationic polymers (branched polyethyleneimine, PEI) by the solvent shifting method for a gene loading. Using our magnetic nanovector system (PEI-coated MnFe₂O₄ nanoparticles), thus, we synchronized stem cell migration and its gene expression in a rat stroke mod
Full Text
http://www.sciencedirect.com/science/article/pii/S0142961211003899
DOI
10.1016/j.biomaterials.2011.04.007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93439
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