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Cytogenetics and prognosis for uveal melanoma in Korean patients

 Christopher Seungkyu Lee  ;  Junwon Lee  ;  Jun Jeong Choi  ;  Woo Ik Yang  ;  Jin Sook Yoon  ;  Sang Yeul Lee  ;  Sung Chul Lee 
 ACTA OPHTHALMOLOGICA, Vol.89(4) : 310-314, 2011 
Journal Title
Issue Date
Adult ; Aged ; Chromosome Aberrations* ; Chromosomes, Human, Pair 3/genetics* ; Chromosomes, Human, Pair 8/genetics* ; Cytogenetic Analysis ; Eye Enucleation ; Female ; Humans ; In Situ Hybridization, Fluorescence ; Korea/epidemiology ; Liver Neoplasms/genetics* ; Liver Neoplasms/mortality ; Liver Neoplasms/secondary ; Male ; Melanoma/genetics* ; Melanoma/mortality ; Melanoma/secondary ; Middle Aged ; Prognosis ; Retrospective Studies ; Survival Rate ; UvealNeoplasms/genetics* ; UvealNeoplasms/mortality ; UvealNeoplasms/pathology
cytogenetics ; Korea ; neoplasia ; uveal melanoma
PURPOSE: To determine the rate of mortality for uveal melanoma in the Korean population and assess whether it correlates with cytogenetic data, and clinical and histopathological factors.

METHODS: A retrospective review of medical files from 33 uveal melanoma patients who underwent enucleation at Yonsei University, Seoul, Korea, between January, 1994 and December, 2009 was performed. Dual-colour fluorescence in situ hybridization was performed using centromeric probes for chromosome 3 and 8 in archived patient tissues.

RESULTS: The mean age of patients was 53.2 years (range; 29-78), and the mean largest basal diameter was 11.8 mm (range; 6.0-18.1). Of the 20 tissue blocks with available cytogenetic data, there was monosomy 3 in seven (35%) and polysomy 8 in four (20%). The presence of monosomy 3 (p < 0.001), polysomy 8 (p < 0.001), ciliary body involvement (p < 0.001), a mitotic rate ≥5/40 high-power fields (p = 0.006), closed extravascular matrix loop (p = 0.025), large basal tumour diameter (p = 0.029) and epithelioid cellularity (p = 0.038) predicted melanoma-related mortality. The median time from enucleation to liver metastasis was 16 months (range; 10-70), and the median survival after metastasis was 5 months (range; 1-9). The Kaplan--Meier survival curve estimated the metastatic death rate to be 22% for 5 years and 30% for 10 years.

CONCLUSIONS: Korean patients with uveal melanoma are younger and appear to exhibit no worse prognosis than Caucasian. Cytogenetic abnormality of chromosome 3 and 8 highly predicted metastatic death.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Yoon, Jin Sook(윤진숙) ORCID logo https://orcid.org/0000-0002-8751-9467
Lee, Sang Yeul(이상열)
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
Lee, Christopher Seungkyu(이승규) ORCID logo https://orcid.org/0000-0001-5054-9470
Lee, Jun Won(이준원) ORCID logo https://orcid.org/0000-0003-0543-7132
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