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Krüppel-like factor 4 (KLF4) activates the transcription of the gene for the platelet isoform of phosphofructokinase (PFKP) in breast cancer

Authors
 Jong-Seok Moon  ;  Hee Eun Kim  ;  Byeong-Woo Park  ;  Won-Ji Jin  ;  Se Ho Park  ;  Kyung-Sup Kim  ;  Sahng Wook Park  ;  Eunjin Koh 
Citation
 Journal of Biological Chemistry, Vol.286(27) : 23808-23816, 2011 
Journal Title
 Journal of Biological Chemistry 
ISSN
 0021-9258 
Issue Date
2011
Abstract
Krüppel-like factor 4 (KLF4) is a transcription factor that plays an important role in cell differentiation, proliferation, and survival, especially in the context of cancers. This study revealed that KLF4 activates glycolytic metabolism in breast cancer cells by up-regulating the platelet isoform of phosphofructokinase (PFKP). KLF4 activated the transcription of the PFKP gene by directly binding to the PFKP promoter. Whereas glucose uptake and lactate production were inhibited by the knockdown of KLF4, they were activated by the overexpression of KLF4. Unlike PFKP, the expressions of the other isoforms of phosphofructokinase and glycolytic genes were unaffected by KLF4. The human breast cancer tissues showed a close correlation between KLF4 and PFKP expression. This study also showed that PFKP plays a critical role in cell proliferation in breast cancer cells. In conclusion, it is suggested that KLF4 plays a role in maintenance of high glycolytic metabolism by transcriptional activation of the PFKP gene in breast cancer cells.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93364
DOI
10.1074/jbc.M111.236737
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Biochemistry & Molecular Biology (생화학-분자생물학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Life Science (의생명과학부)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터)
Yonsei Authors
고은진(Koh, Eun Jin) ; 김경섭(Kim, Kyung Sup) ; 김희은(Kim, Hee Eun) ; 문종석(Moon, Jong-Seok) ; 박병우(Park, Byeong Woo) ; 박상욱(Park, Sahng Wook) ; 박세호(Park, Se Ho) ; 진원지(Jin, Won Ji)
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