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Ideal Experimental Rat Models for Liver Diseases

Authors
 Sang Woo Lee  ;  Sung Hoon Kim  ;  Seon Ok Min  ;  Kyung Sik Kim 
Citation
 Korean Journal of Hepato-Biliary-Pancreatic Surgery, Vol.15(2) : 67-77, 2011 
Journal Title
Korean Journal of Hepato-Biliary-Pancreatic Surgery(한국간담췌외과학회지)
ISSN
 1738-6349 
Issue Date
2011
Keywords
Animal model ; Liverdisease ; Rat
Abstract
There are many limitations for conducting liver disease research in human beings due to the high cost and potential ethical issues. For this reason, conducting a study that is difficult to perform in humans using appropriate animal models, can be beneficial in ascertaining the pathological physiology, and in developing new treatment modalities. However, it is difficult to determine the appropriate animal model which is suitable for research purposes, since every patient has different and diverse clinical symptoms, adverse reactions, and complications due to the pathological physiology. Also, it is not easy to reproduce identically various clinical situations in animal models. Recently, the Guide for the Care and Use of Laboratory Animals has tightened up the regulations, and therefore it is advisable to select the appropriate animals and decide upon the appropriate quantities through scientific and systemic considerations before conducting animal testing. Therefore, in this review article the authors examined various white rat animal testing models and determined the appropriate usable rat model, and the pros and cons of its application in liver disease research. The authors believe that this review will be beneficial in selecting proper laboratory animals for research purposes.
Files in This Item:
T201101583.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Sung Hoon(김성훈)
Min, Seon Ok(민선옥)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93348
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