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Timetable for upper eyelid development in staged human embryos and fetuses.

Authors
 TAE HO BYUN  ;  JEONG TAE KIM  ;  HYOUNG WOO PARK  ;  WON KYU KIM 
Citation
 ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, Vol.294(5) : 789-796, 2011 
Journal Title
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
ISSN
 1932-8486 
Issue Date
2011
MeSH
Embryo, Mammalian/cytology* ; Eyelids/anatomy & histology* ; Eyelids/growth & development* ; Fetus/cytology* ; Humans ; Time Factors
Abstract
In this study, we examined the development of the upper eyelids to provide a basic understanding of gross anatomical structures and information relative to mechanisms of congenital anomalies in the upper eyelids. We studied the upper eyelids by external and histological observation in 48 human embryos and in fetuses from 5 to 36 weeks postfertilization. The upper eyelid fold began to develop at Stage 18. Upper and lower eyelids fused from the lateral cantus at Stage 22, and fusion was complete by 9 weeks of development. Mesenchymal condensations forming the orbital part of the orbicularis oculi (OO), tarsal plate, and the eyelashes and their appendages, were first seen at Week 9. Definite muscle structures of the upper eyelid, such as the orbital part of the OO and the levator palpebrae superioris and its aponeurosis, and the Müller's muscle were observed at 12 and 14 weeks, respectively. In addition, orbital septum, arterial arcade and orbital fat pad, and tarsal gland (TG) were apparent at 12, 14, and 18 weeks, respectively. Opening of the palpebral fissure was observed at Week 20. In addition, we defined the directional orientation between the levator aponeurosis and orbital septum and the growth pattern of the TG. Our results will be helpful in understanding the normal development of the upper eyelid and the origins of upper eyelid birth defects.
Files in This Item:
T201101368.pdf Download
DOI
10.1002/ar.21366
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyoung Woo(박형우) ORCID logo https://orcid.org/0000-0002-5341-9249
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93179
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