Cited 10 times in
Impact of High-Dose Statin Pretreatment in Patients with Stable Angina during Off-Pump Coronary Artery Bypass.
DC Field | Value | Language |
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dc.contributor.author | 유경종 | - |
dc.contributor.author | 윤영남 | - |
dc.contributor.author | 주현철 | - |
dc.date.accessioned | 2014-12-20T16:40:35Z | - |
dc.date.available | 2014-12-20T16:40:35Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 2233-601X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93165 | - |
dc.description.abstract | BACKGROUND: Periprocedural treatment with high-dose statins is known to have cardioprotective and pleiotropic effects, such as anti-thrombotic and anti-inflammatory actions. We aimed to assess the efficacy of high-dose rosuvastatin loading in patients with stable angina undergoing off-pump coronary artery bypass grafting (OPCAB). MATERIALS AND METHODS: A total of 142 patients with stable angina who were scheduled to undergo surgical myocardial revascularization were randomized to receive either pre-treatment with 60-mg rosuvastatin (rosuvastatin group, n=71) or no pre-treatment (control group, n=71) before OPCAB. The primary endpoint was the 30-day incidence of major adverse cardiac events (MACEs). The secondary endpoint was the change in the degree of myocardial ischemia as evaluated with creatine kinase-myocardial band (CK-MB) and troponin T (TnT). RESULTS: There were no significant intergroup differences in preoperative risk factors or operative strategy. MACEs within 30 days after OPCAB occurred in one patient (1.4%) in the rosuvastatin group and four patients (5.6%) in the control group, respectively (p=0.37). Preoperative CK-MB and TnT were not different between the groups. After OPCAB, the mean maximum CK-MB was significantly higher in the control group (rosuvastatin group 10.7+/-9.75 ng/mL, control group 14.6+/-12.9 ng/mL, p=0.04). Furthermore, the mean levels of maximum TnT were significantly higher in the control group (rosuvastatin group 0.18+/-0.16 ng/mL, control group 0.39+/-0.70 ng/mL, p=0.02). CONCLUSION: Our findings suggest that high-dose rosuvastatin loading before OPCAB surgery did not result in a significant reduction of 30-day MACEs. However, high-dose rosuvastatin reduced myocardial ischemia after OPCAB. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 208~214 | - |
dc.language | English | - |
dc.publisher | Korean Society for Thoracic and Cardiovascular Surgery | - |
dc.relation.isPartOf | Korean Journal of Thoracic and Cardiovascular Surgery | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Impact of High-Dose Statin Pretreatment in Patients with Stable Angina during Off-Pump Coronary Artery Bypass. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic & Cardiovascular Surgery (흉부외과학) | - |
dc.contributor.googleauthor | Young-Nam Youn | - |
dc.contributor.googleauthor | Seong-Yong Park | - |
dc.contributor.googleauthor | Yoohwa Hwang | - |
dc.contributor.googleauthor | Huyn-Chul Joo | - |
dc.contributor.googleauthor | Kyung-Jong Yoo | - |
dc.identifier.doi | 10.5090/kjtcs.2011.44.3.208 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02453 | - |
dc.contributor.localId | A02576 | - |
dc.contributor.localId | A03960 | - |
dc.relation.journalcode | J02126 | - |
dc.identifier.eissn | 2093-6516 | - |
dc.identifier.pmid | 22263153 | - |
dc.subject.keyword | Coronary artery bypass | - |
dc.subject.keyword | Off-pump | - |
dc.subject.keyword | Statin | - |
dc.contributor.alternativeName | Yoo, Kyung Jong | - |
dc.contributor.alternativeName | Youn, Young Nam | - |
dc.contributor.alternativeName | Joo, Hyun Chel | - |
dc.contributor.affiliatedAuthor | Yoo, Kyung Jong | - |
dc.contributor.affiliatedAuthor | Youn, Young Nam | - |
dc.contributor.affiliatedAuthor | Joo, Hyun Chel | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 44 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 208 | - |
dc.citation.endPage | 214 | - |
dc.identifier.bibliographicCitation | Korean Journal of Thoracic and Cardiovascular Surgery, Vol.44(3) : 208-214, 2011 | - |
dc.identifier.rimsid | 27027 | - |
dc.type.rims | ART | - |
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